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Heterogeneity in the Prevalence of High-Risk Human Papillomavirus Infection in Human Immunodeficiency Virus-Negative and Human Immunodeficiency Virus-Positive Men Who Have Sex With Men in West Africa
- Source :
- Clinical Infectious Diseases, Clinical Infectious Diseases, 2021, 73, pp.2184-2192. ⟨10.1093/cid/ciab157⟩, Clinical Infectious Diseases, Oxford University Press (OUP), 2021, 73, pp.2184-2192. ⟨10.1093/cid/ciab157⟩
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- Background Men who have sex with men (MSM) are at high risk of human papillomavirus (HPV) infection. We assessed (i) the prevalence of high-risk HPV (HR-HPV) infection and associated factors, and (ii) the prevalence of vaccine-preventable HPV infections in MSM in Burkina Faso, Côte d’Ivoire, Mali, and Togo. Methods A cross-sectional study was conducted in 2017–2018 among MSM ≥18 years old followed in community-based clinics. HPV infection was investigated in oral and anal samples using the e-BRID system. Factors associated with HR-HPV infection were identified using multivariate logistic regressions. Results Among 631 participants, 425 were HIV-negative and 206 HIV-positive. HR-HPV prevalence ranged from 9.2% to 34.8% in the former, and 33.3% to 71.0% in the latter, according to the study country. In multivariate analysis, HIV infection (adjusted odds ratio (aOR) 3.61, 95% confidence interval (CI) 2.48–5.27) and study country (4.73, 2.66–8.43 for Mali; 3.12, 1.68–5.80 for Burkina Faso; 3.51, 1.92–6.42 for Togo) were associated with HR-HPV infection. Other associated factors were low educational level, self-defined homosexual identity, and condomless anal sex. The prevalence of infections which can be prevented with bivalent, quadrivalent, and nonavalent vaccines was 5.9, 27.1, and 34.6% in HIV-negative participants, and 18.9, 43.7, and 54.9% in HIV-positive participants, respectively. Conclusions HR-HPV prevalence was very heterogeneous between the study countries in both HIV-negative and HIV-positive MSM. Vaccine-preventable HPV infections predominated. Vaccination should be proposed to young MSM to reduce the burden of HPV infection in this vulnerable population and their female partners in West Africa.
- Subjects :
- Male
Microbiology (medical)
HPV
Multivariate analysis
Adolescent
[SDV]Life Sciences [q-bio]
MSM
Human immunodeficiency virus (HIV)
Anal Canal
HIV Infections
Logistic regression
medicine.disease_cause
Men who have sex with men
Sexual and Gender Minorities
03 medical and health sciences
0302 clinical medicine
Risk Factors
Burkina Faso
Prevalence
medicine
Humans
030212 general & internal medicine
Homosexuality, Male
Papillomaviridae
business.industry
Papillomavirus Infections
HPV infection
HIV
virus diseases
Odds ratio
medicine.disease
Confidence interval
[SDV] Life Sciences [q-bio]
Vaccination
Cross-Sectional Studies
Infectious Diseases
030220 oncology & carcinogenesis
Africa
Female
business
Demography
Subjects
Details
- ISSN :
- 15376591 and 10584838
- Volume :
- 73
- Database :
- OpenAIRE
- Journal :
- Clinical Infectious Diseases
- Accession number :
- edsair.doi.dedup.....7323d4fca5c48e9be15aed6ced2b5d5d
- Full Text :
- https://doi.org/10.1093/cid/ciab157