Comment on Wędrychowicz et al. Like-triple diabetes as first manifestation of MODY2 in an overweight teenager with transient multiple antibodies. Diabetes care 2014;37:e66-e67

We read with interest the article by Wedrychowicz et al. (1). Maturity-onset diabetes of the young (MODY) is a heterogeneous group of monogenic forms of diabetes. Differential diagnosis with common forms such as type 1 and type 2 diabetes frequently poses a challenge to clinicians, especially in MODY forms caused by transcription factors. Glucokinase ( GCK )-MODY stands out in this regard for displaying a rather constant phenotype (2). We agree with the authors that the incidental association of obesity with GCK mutations can act as a diagnostic confounder. Moreover, coexistence of clinical features of both type 1 and type 2 diabetes is well described in …