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Evaluation of placental vascularization in thrombophilia and intrauterine growth restriction (IUGR)
- Source :
- Romanian Journal of Morphology and Embryology
- Publication Year :
- 2021
-
Abstract
- The placenta is an essential organ in the proper development of pregnancy, and it can present a lot of structural and vascular lesions that can affect fetal development. One of the pathologies associated with pregnancy, which can change the placental structure is thrombophilia (TPh), and this can be correlated with an intrauterine growth restriction (IUGR) of the fetus. Maternal clinical aspects (age, weight) can be correlated with fetal ones (weight, gender), but also with the structural and vascular aspect of the placenta. The placental structure associated with TPh and IUGR shows macroscopic changes, such as fibrin deposition, calcifications and placental infarctions, but microscopic lesions are best highlighted by classical staining techniques: Hematoxylin-Eosin (HE), Masson's trichrome (MT) and Periodic Acid-Schiff (PAS)-Hematoxylin, but also by immunohistochemistry technique with the help of anti-cluster of differentiation 34 (CD34) antibody that could make it possible to quantify vascular density depending on the pathology. Microscopic changes were massive infarcts caused by vascular ischemia, intravenous and extravillous fibrin deposits, calcifications, and vascular thrombosis. All these clinical, morphological and morphopathological data are interconnected and may vary in the presence of TPh and IUGR.
- Subjects :
- Adult
Embryology
Pathology
medicine.medical_specialty
Adolescent
placenta
CD34
Intrauterine growth restriction
Thrombophilia
infarcts
Fibrin
Pathology and Forensic Medicine
03 medical and health sciences
Young Adult
0302 clinical medicine
vascularization
Trichrome
Pregnancy
Placenta
medicine
Humans
Fetus
Original Paper
030219 obstetrics & reproductive medicine
Fetal Growth Retardation
biology
business.industry
Cell Biology
General Medicine
medicine.disease
medicine.anatomical_structure
030220 oncology & carcinogenesis
embryonic structures
fibrin depositions
biology.protein
Female
business
Developmental Biology
Subjects
Details
- ISSN :
- 20668279
- Volume :
- 61
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
- Accession number :
- edsair.doi.dedup.....72fa8d8bd48882dc58bead2dc11b2aff