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Inhalation Toxicology of Vaping Products and Implications for Pulmonary Health
- Source :
- International Journal of Molecular Sciences, Vol 21, Iss 3495, p 3495 (2020), International Journal of Molecular Sciences
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- E-cigarettes have a liquid that may contain flavors, solvents, and nicotine. Heating this liquid generates an aerosol that is inhaled into the lungs in a process commonly referred to as vaping. E-cigarette devices can also contain cannabis-based products including tetrahydrocannabinol (THC), the psychoactive component of cannabis (marijuana). E-cigarette use has rapidly increased among current and former smokers as well as youth who have never smoked. The long-term health effects are unknown, and emerging preclinical and clinical studies suggest that e-cigarettes may not be harmless and can cause cellular alterations analogous to traditional tobacco smoke. Here, we review the historical context and the components of e-cigarettes and discuss toxicological similarities and differences between cigarette smoke and e-cigarette aerosol, with specific reference to adverse respiratory outcomes. Finally, we outline possible clinical disorders associated with vaping on pulmonary health and the recent escalation of acute lung injuries, which led to the declaration of the vaping product use-associated lung injury (EVALI) outbreak. It is clear there is much about vaping that is not understood. Consequently, until more is known about the health effects of vaping, individual factors that need to be taken into consideration include age, current and prior use of combustible tobacco products, and whether the user has preexisting lung conditions such as asthma and chronic obstructive pulmonary disease (COPD).
- Subjects :
- 0301 basic medicine
Lung Diseases
cannabis
vitamin E acetate
Inhalation Toxicology
Review
Tobacco smoke
Nicotine
lcsh:Chemistry
0302 clinical medicine
vaping
030212 general & internal medicine
Lung
lcsh:QH301-705.5
Spectroscopy
COPD
Inhalation Exposure
biology
EVALI
General Medicine
e-cigarettes
cannabinoid
Computer Science Applications
medicine.drug
medicine.medical_specialty
Cells
Context (language use)
Lung injury
Catalysis
lipoid pneumonia
Cigarette Smoking
Inorganic Chemistry
03 medical and health sciences
medicine
Humans
Physical and Theoretical Chemistry
lung injury
Intensive care medicine
Molecular Biology
Asthma
business.industry
Organic Chemistry
biology.organism_classification
medicine.disease
respiratory
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
inflammation
Cannabis
business
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 21
- Issue :
- 3495
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....72f578bcacd13e28b6ac319d5bcbd597