Back to Search
Start Over
Acidic Fibroblast Growth Factor Accelerates the Healing of Acetic-Acid-lnduced Gastric Ulcers in Rats
- Source :
- Digestion. 53:17-27
- Publication Year :
- 1992
- Publisher :
- S. Karger AG, 1992.
-
Abstract
- Acidic fibroblast growth factor (aFGF) was evaluated for the healing of acetic-acid-induced gastric ulcers in rats. The effect of aFGF on angiogenesis in the gastric ulcer bed was determined by the carmine dye infusion method, while its effect on gastric acid secretion was assessed in chronic gastric fistula rats. Oral treatment with aFGF, in the presence of heparin, reduced (ED50 value = 30.2 micrograms/kg/day) the acetic-acid-induced gastric ulcer area, when assessed 1 week later. aFGF was about 1,333-fold more potent than famotidine for healing such ulcers. At a dose of 200 micrograms/kg/day, aFGF increased the carmine density 3-fold and correspondingly reduced (80%) the gastric ulcer area. Thus, the ulcer healing effect of this agent involves angiogenesis in the gastric ulcer bed. This effect of aFGF appears to be unrelated to an inhibition of gastric acid secretion, as it was ineffective in chronic gastric fistula rats. In summary, oral aFGF significantly accelerates the healing of experimental gastric ulcers in rats. It may be a potent and effective agent for the treatment of peptic ulcers in humans.
- Subjects :
- medicine.medical_specialty
Magnesium Hydroxide
Time Factors
Angiogenesis
medicine.medical_treatment
Aluminum Hydroxide
Acetates
Fibroblast growth factor
Gastric Acid
Rats, Sprague-Dawley
Acetic acid
chemistry.chemical_compound
Oral administration
Internal medicine
medicine
Animals
Stomach Ulcer
Acidic Fibroblast Growth Factor
Acetic Acid
Wound Healing
Chemotherapy
Neovascularization, Pathologic
Chemistry
Stomach
digestive, oral, and skin physiology
Gastroenterology
Famotidine
Recombinant Proteins
digestive system diseases
Rats
Drug Combinations
Endocrinology
medicine.anatomical_structure
Gastric Mucosa
Fibroblast Growth Factor 1
Female
Antacids
Subjects
Details
- ISSN :
- 14219867 and 00122823
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Digestion
- Accession number :
- edsair.doi.dedup.....72eed56b992ef172910cf8259dec5fef