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Cancer risks in first-degree relatives of CHEK2 mutation carriers: effects of mutation type and cancer site in proband
- Source :
- British Journal of Cancer
- Publication Year :
- 2009
- Publisher :
- Springer Science and Business Media LLC, 2009.
-
Abstract
- It is important to have accurate knowledge of the range of cancers associated with various CHEK2 mutations, and of the lifetime risks of cancer associated with each. We wished to establish the relationship between family history, mutation type and cancer risk in families with a CHEK2 mutation. We obtained a blood sample and pedigree information from 2012 unselected women with breast cancer, from 2007 men with prostate cancer and from 1934 patients with colon cancer, from hospitals throughout Poland. Genetic testing was carried out for four founder CHEK2 mutations on all 5953 specimens and 533 carriers were identified. We estimated the risk to age 75 for any cancer in the 2544 first-degree relatives to be 22.3%. After adjusting for mutation type, the risk of breast cancer was much higher among relatives of probands with breast cancer than among relatives of patients with prostate or colon cancer (HR=3.6; 95% CI=2.1-6.2; P=0.0001). Similarly, the risk of prostate cancer was higher among relatives of probands with prostate cancer than among relatives of patients with breast or colon cancer (HR=4.4; 95% CI=2.2-8.7; P=0.0001) and the risk of colon cancer was higher among relatives of probands with colon cancer than among relatives of patients with prostate or breast cancer (HR=4.2; 95% CI=2.4-7.8; P=0.0001). These analyses suggest that the risk of cancer in a carrier of a CHEK2 mutation is dependent on the family history of cancer.
- Subjects :
- Male
Oncology
Cancer Research
medicine.medical_specialty
Epidemiology
Colorectal cancer
Breast Neoplasms
Protein Serine-Threonine Kinases
Prostate cancer
breast cancer
Breast cancer
Neoplasms
Internal medicine
medicine
Humans
Family
First-degree relatives
Risk factor
skin and connective tissue diseases
CHEK2
Gynecology
business.industry
Genetic Carrier Screening
Prostatic Neoplasms
Cancer
prostate cancer
medicine.disease
Checkpoint Kinase 2
colon cancer
Carrier State
Colonic Neoplasms
Mutation
Female
Breast disease
business
Subjects
Details
- ISSN :
- 15321827 and 00070920
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- British Journal of Cancer
- Accession number :
- edsair.doi.dedup.....72ee34a4ce98fd89186cb59bbb873949