Back to Search
Start Over
Re: Contrasting Epidemiology and Clinicopathology of Female Breast Cancer in Asians vs the US Population
- Source :
- J Natl Cancer Inst
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- BackgroundThe incidence of breast cancer among younger East Asian women has been increasing rapidly over recent decades. This international collaborative study systemically compared the differences in age-specific incidences and pathological characteristics of breast cancer in East Asian women and women of predominantly European ancestry.MethodsWe excerpted analytic data from six national cancer registries (979 675 cases) and eight hospitals (18 008 cases) in East Asian countries and/or regions and, for comparisons, from the US Surveillance, Epidemiology, and End Results program database. Linear regression analyses of age-specific incidences of female breast cancer and logistic regression analyses of age-specific pathological characteristics of breast cancer were performed. All statistical tests were two-sided.ResultsUnlike female colorectal cancer, the age-specific incidences of breast cancer among East Asian women aged 59 years and younger increased disproportionally over recent decades relative to rates in US contemporaries. For years 2010–2014, the estimated age-specific probability of estrogen receptor positivity increased with age in American patients, whereas that of triple-negative breast cancer (TNBC) declined with age. No similar trends were evident in East Asian patients; their probability of estrogen receptor positivity at age 40–49 years was statistically significantly higher (odd ratio [OR] = 1.50, 95% confidence interval [CI] = 1.36 to 1.67, P < .001) and of TNBC was statistically significantly lower (OR = 0.79, 95% CI = 0.71 to 0.88, P < .001), whereas the probability of ER positivity at age 50–59 years was statistically significantly lower (OR = 0.88, 95% CI = 0.828 to 0.95, P < .001). Subgroup analyses of US Surveillance, Epidemiology, and End Results data showed similarly distinct patterns between East Asian American and white American patients.ConclusionsContrasting age-specific incidences and pathological characteristics of breast cancer between East Asian and American women, as well as between East Asian Americans and white Americans, suggests racial differences in the biology.
- Subjects :
- Cancer Research
Colorectal cancer
Receptor, ErbB-2
Triple Negative Breast Neoplasms
0302 clinical medicine
Epidemiology
Odds Ratio
Medicine
Registries
Triple-negative breast cancer
Aged, 80 and over
0303 health sciences
Singapore
education.field_of_study
Asia, Eastern
Incidence (epidemiology)
Incidence
Age Factors
Middle Aged
Receptors, Estrogen
Oncology
030220 oncology & carcinogenesis
Female
Adult
medicine.medical_specialty
Population
MEDLINE
Breast Neoplasms
White People
Immunophenotyping
03 medical and health sciences
Breast cancer
Republic of Korea
Correspondence
Confidence Intervals
Humans
education
030304 developmental biology
Aged
Female breast cancer
Asian
business.industry
Cancer
medicine.disease
Confidence interval
United States
Linear Models
business
SEER Program
Demography
Subjects
Details
- ISSN :
- 14602105 and 00278874
- Volume :
- 112
- Database :
- OpenAIRE
- Journal :
- JNCI: Journal of the National Cancer Institute
- Accession number :
- edsair.doi.dedup.....72ea1c1dcf4432703060b13f2e9c93db