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Effectiveness of antiplatelet therapy for Kawasaki disease: a systematic review
- Source :
- European Journal of Pediatrics. 178:947-955
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Kawasaki disease is an acute systemic vasculitis in children. Antiplatelet medicines are commonly used for Kawasaki disease to attenuate vasculitis and prevent thromboembolism; however, the mechanisms have not been elucidated. The objective of this study is to assess the effectiveness of antiplatelet medications for Kawasaki disease. We used Medline, Embase, Cochrane Central Register of Controlled Trials, and Igaku Chuo Zasshi (Ichushi) from January 1947 to August 2018. Studies describing the platelet functions of antiplatelet drugs for Kawasaki disease were included. Twenty studies met the inclusion criteria. There were no randomized controlled trials. Seven studies compared platelet aggregation ability before and after treatment. Eight studies compared platelet aggregation with that in Kawasaki disease patients without treatment. Four studies compared aggregation among different types of antiplatelet drugs or at different doses. Antiplatelet medications administered in the studies included aspirin, flurbiprofen, dipyridamole, and choline salicylate. Methods for the measurement of platelet aggregation ability varied among studies. The groups with antiplatelet treatment tended to have a decreased platelet aggregation function. The statistical analyses were impossible due to insufficient quantitative data and heterogeneity among the studies.Conclusion: The present systematic review revealed that there was insufficient evidence for the effectiveness of antiplatelet therapy for Kawasaki disease. What is Known: • Antiplatelet therapy is widely used for Kawasaki disease to mitigate cardiac complications. • The mechanisms of antiplatelet therapy for Kawasaki disease are not clarified. What is New: • This systematic review showed that the groups with antiplatelet treatment tended to have a decreased platelet aggregation function. • There is insufficient evidence for the effectiveness of antiplatelet therapy for Kawasaki disease.
- Subjects :
- Male
medicine.medical_specialty
Platelet Aggregation
MEDLINE
Mucocutaneous Lymph Node Syndrome
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
030225 pediatrics
Internal medicine
medicine
Humans
Platelet
cardiovascular diseases
030212 general & internal medicine
Child
Aspirin
Dose-Response Relationship, Drug
business.industry
medicine.disease
Dipyridamole
Treatment Outcome
Pediatrics, Perinatology and Child Health
Female
Kawasaki disease
Vasculitis
business
Platelet Aggregation Inhibitors
Systemic vasculitis
medicine.drug
Subjects
Details
- ISSN :
- 14321076 and 03406199
- Volume :
- 178
- Database :
- OpenAIRE
- Journal :
- European Journal of Pediatrics
- Accession number :
- edsair.doi.dedup.....72ddf2e3669288cdba0f4d1064020c13