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Differences in UGT1A1, UGT1A7, and UGT1A9 Polymorphisms between Uzbek and Japanese Populations
- Source :
- Molecular Diagnosis & Therapy
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- Background and Objectives Uridine-diphosphate glucuronosyltransferase 1A (UGT1A) is a key enzyme involved in irinotecan metabolism, and polymorphisms in the UGT1A gene are associated with irinotecan-induced toxicity. The aim of this study was to elucidate the allele frequencies of UGT1A polymorphisms in healthy Uzbek volunteers, and to compare them with those of the Japanese population. Method A total of 97 healthy volunteers from Uzbekistan were enrolled and blood samples were collected from each participant. Genotyping analysis was performed by fragment size analysis for UGT1A1*28, direct sequencing for UGT1A7*3 and UGT1A9*22, and TaqMan assays for UGT1A1*93, UGT1A1*6, UGT1A1*27, UGT1A1*60, and UGT1A7*12. The frequencies of polymorphisms were compared with the Japanese population by using the data previously reported from our study group. Results When the Uzbek and Japanese populations were compared, heterozygotes or homozygotes for UGT1A1*28, UGT1A1*60, and UGT1A1*93 were significantly more frequent in the Uzbek population (P
- Subjects :
- Glucuronosyltransferase
Genotype
Population
digestive system
Polymorphism, Single Nucleotide
White People
Asian People
Gene Frequency
Japan
Genetic variation
Genetics
medicine
Humans
Original Research Article
education
Allele frequency
Medicine(all)
Pharmacology
education.field_of_study
biology
Genetic Variation
Uzbekistan
General Medicine
Human genetics
Uzbek
language.human_language
Irinotecan
Genetics, Population
UDP-Glucuronosyltransferase 1A9
biology.protein
language
Molecular Medicine
medicine.drug
Subjects
Details
- ISSN :
- 11792000 and 11771062
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Molecular Diagnosis & Therapy
- Accession number :
- edsair.doi.dedup.....72da37d0f1df91a00a3f0fe636420d0d