Back to Search
Start Over
RNA interference targeting human FAK and EGFR suppresses human non-small-cell lung cancer xenograft growth in nude mice
- Source :
- Cancer Gene Therapy. 20:101-108
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Transfection of plasmid vectors coexpressing short hairpin RNA (shRNA) for focal adhesion kinase (FAK) and epidermal growth factor receptor (EGFR) significantly inhibited protein level of FAK and EGFR. Knockdown of FAK and EGFR expression significantly inhibited cell proliferation and induced cell apoptosis of A549 lung cancer cells in vitro. In A549 subcutaneous xenograft model, mice treated for 3 weeks with plasmid that coexpresses FAK and EGFR shRNA had significantly smaller tumors than those in control mice (P
- Subjects :
- Cancer Research
Genetic Vectors
Apoptosis
Focal adhesion
Small hairpin RNA
Mice
RNA interference
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
Animals
Humans
Gene silencing
Epidermal growth factor receptor
RNA, Small Interfering
Molecular Biology
Cell Proliferation
Gene knockdown
biology
Chemistry
Cell growth
Genetic Therapy
Transfection
Xenograft Model Antitumor Assays
Molecular biology
ErbB Receptors
Gene Expression Regulation, Neoplastic
Focal Adhesion Kinase 1
biology.protein
Molecular Medicine
RNA Interference
Subjects
Details
- ISSN :
- 14765500 and 09291903
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Cancer Gene Therapy
- Accession number :
- edsair.doi.dedup.....72c09fc52c198b165a606f305d026edf