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Subthalamic Nucleus and Sensorimotor Cortex Activity During Speech Production
- Source :
- CONICET Digital (CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, instacron:CONICET
- Publication Year :
- 2019
- Publisher :
- Society for Neuroscience, 2019.
-
Abstract
- The sensorimotor cortex is somatotopically organized to represent the vocal tract articulators such as lips, tongue, larynx, and jaw. How speech and articulatory features are encoded at the subcortical level, however, remains largely unknown. We analyzed LFP recordings from the subthalamic nucleus (STN) and simultaneous electrocorticography recordings from the sensorimotor cortex of 11 human subjects (1 female) with Parkinson´s disease during implantation of deep-brain stimulation (DBS) electrodes while they read aloud three-phoneme words. The initial phonemes involved either articulation primarily with the tongue (coronal consonants) or the lips (labial consonants). We observed significant increases in high-gamma (60?150 Hz) power in both the STN and the sensorimotor cortex that began before speech onset and persisted for the duration of speech articulation. As expected from previous reports, in the sensorimotor cortex, the primary articulators involved in the production of the initial consonants were topographically represented by high-gamma activity. We found that STN high-gamma activity also demonstrated specificity for the primary articulator, although no clear topography was observed. In general, subthalamic high-gamma activity varied along the ventral?dorsal trajectory of the electrodes, with greater high-gamma power recorded in the dorsal locations of the STN. Interestingly, the majority of significant articulator-discriminative activity in the STN occurred before that in sensorimotor cortex. These results demonstrate that articulator-specific speech information is contained within high-gamma activity of the STN, but with different spatial and temporal organization compared with similar information encoded in the sensorimotor cortex. Fil: Chrabaszcz, Anna. University of Pittsburgh; Estados Unidos Fil: Neumann, Wolf Julian. Universität zu Berlin; Alemania Fil: Stretcu, Otilia. University of Pittsburgh; Estados Unidos Fil: Lipski, Witold J.. University of Pittsburgh; Estados Unidos Fil: Dastolfo Hromack, Christina A.. University of Pittsburgh; Estados Unidos Fil: Bush, Alan. University of Pittsburgh; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina Fil: Wang, Dengyu. Tsinghua University; China. University of Pittsburgh; Estados Unidos Fil: Crammond, Donald J.. University of Pittsburgh; Estados Unidos Fil: Shaiman, Susan. University of Pittsburgh; Estados Unidos Fil: Dickey, Michael W.. University of Pittsburgh; Estados Unidos Fil: Holt, Lori L.. University of Pittsburgh; Estados Unidos Fil: Turner, Robert S.. University of Pittsburgh; Estados Unidos Fil: Fiez, Julie A.. University of Pittsburgh; Estados Unidos Fil: Richardson, R. Mark. University of Pittsburgh; Estados Unidos
- Subjects :
- Male
Speech production
Deep brain stimulation
medicine.medical_treatment
Local field potential
Biology
PARKINSON’S DISEASE
03 medical and health sciences
0302 clinical medicine
Subthalamic Nucleus
Basal ganglia
medicine
Humans
Speech
purl.org/becyt/ford/3.4 [https]
Electrocorticography
Research Articles
030304 developmental biology
Aged
0303 health sciences
Brain Mapping
ELECTROCORTICOGRAPHY
medicine.diagnostic_test
SUBTHALAMIC NUCLEUS
General Neuroscience
DEEP BRAIN STIMULATION
SPEECH
Middle Aged
Manner of articulation
Electrophysiology
Subthalamic nucleus
nervous system
purl.org/becyt/ford/3 [https]
Female
Sensorimotor Cortex
Articulation (phonetics)
SENSORIMOTOR CORTEX
Neuroscience
030217 neurology & neurosurgery
Photic Stimulation
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- CONICET Digital (CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, instacron:CONICET
- Accession number :
- edsair.doi.dedup.....72bd1e20348580bfac2d91268aae57bd