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Outcome of segmental prosthesis reconstruction for diaphyseal bone tumors: a multi-center retrospective study
- Source :
- BMC Cancer, BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019)
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Background The optimal reconstructive method after diaphyseal malignant bone tumor resection remains controversial. This multicenter clinical study was designed to investigate the clinical value and complications of segmental prosthesis in the repair of diaphyseal defects. Methods We present 49 patients from three clinical centers treated with wide resection for primary or metastatic bone tumors involving the diaphysis of the femur, tibia, humerus, or ulna, followed by reconstruction using a modular intramedullary segmental prosthesis. Results Enrolled patients included 23 men and 26 women with a mean age of 63.3 years. Of these, seven patients had primary bone tumors and 42 patients had metastatic lesions. At the mean follow-up of 13.7 months, 17 patients were alive, 31 patients were deceased due to tumor progression, and one patient was dead of another reason. There were eight nononcologic complications (two with radial nerve injury, three with delayed incision healing, two with aseptic loosening in the proximal humerus prosthetic stem and one with structural failure) and three oncologic complications (three with primary tumor recurrence) among all patients. The incidence of complications in primary tumor patients (4/7, 57.1%) was higher than that in patients with metastatic tumors (7/42, 16.7%) (p = 0.036). Aseptic loosening and mechanical complications were not common for patients with primary tumors, although the reconstruction length difference was statistically significant (p = 0.023). No statistically significant differences were observed in limb function, while the mean musculoskeletal tumor society score was 21.2 in femora, 19.6 in humeri, and 17.8 in tibiae (p = 0.134). Conclusions Segmental prostheses represent an optional method for the reconstruction of diaphyseal defects in patients with limited life expectancy. Segmental prostheses in the humerus experienced more complications than those used to treat lesions in the femur.
- Subjects :
- Male
0301 basic medicine
Cancer Research
medicine.medical_treatment
Prosthesis
law.invention
Intramedullary rod
0302 clinical medicine
law
Bone reconstruction
Aged, 80 and over
Prostheses and Implants
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Primary tumor
Prosthesis Failure
Retrospective study
Treatment Outcome
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Segmental prostheses
Female
Research Article
Adult
medicine.medical_specialty
Adolescent
Bone Neoplasms
Diaphyseal defects
lcsh:RC254-282
Prosthesis Implantation
Young Adult
03 medical and health sciences
Genetics
medicine
Humans
Femur
Humerus
Tibia
Aged
Retrospective Studies
business.industry
Ulna
Plastic Surgery Procedures
medicine.disease
Surgery
Diaphysis
Diaphysis tumors
030104 developmental biology
Assistant plate
Pathological fractures
Diaphyses
business
Subjects
Details
- ISSN :
- 14712407
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- BMC Cancer
- Accession number :
- edsair.doi.dedup.....72b64bcadf091cb0af5afd500418c79e