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Organic Brain Dysfunction and Cognitive Deficits in Young Schizophrenic Patients with Tardive Dyskinesia
- Source :
- Brain and Cognition. 23:81-87
- Publication Year :
- 1993
- Publisher :
- Elsevier BV, 1993.
-
Abstract
- Tardive dyskinesia (TD) has been associated with cognitive deficits, especially in older psychiatric patients an neuroleptic medication. This study investigated the relationship between presence of TD, organic brain dysfunction (OBD), and cognitive deficits in young psychiatric outpatients maintained on minimal doses of oral neuroleptics, with anticholinergics prescribed only on an as-needed basis. Sixty-four patients, aged 20-39 years, were evaluated for the presence of abnormal movements, localizing and nonlocalizing physical signs, and deficits in memory, ability to shift, and sustained attention. Sixteen patients showed definite signs of TD. Significant associations were found between TD and OBD, and between cognitive deficits and OBD, but not between TD and cognitive deficits. Significant regression predictors of TD were the interaction between OBD and previous dystonia, as well as duration of neuroleptic treatment. These findings suggest that some potential risk factors for TD already identified in the literature also apply to younger patients with relatively shorter exposure to neuroleptics. However, the results indicate that the relationship between movement disorders and cognitive deficits may be more apparent in older patients.
- Subjects :
- Adult
Male
Dyskinesia, Drug-Induced
Psychosis
Pediatrics
medicine.medical_specialty
Movement disorders
Cognitive Neuroscience
Experimental and Cognitive Psychology
Tardive dyskinesia
Basal Ganglia Diseases
Arts and Humanities (miscellaneous)
Organic mental disorders
Developmental and Educational Psychology
medicine
Humans
Psychiatry
Psychiatric Status Rating Scales
Dystonia
Mental Disorders
Cognitive disorder
medicine.disease
Neuropsychology and Physiological Psychology
Dyskinesia
Schizophrenia
Female
medicine.symptom
Cognition Disorders
Psychology
Antipsychotic Agents
Subjects
Details
- ISSN :
- 02782626
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Brain and Cognition
- Accession number :
- edsair.doi.dedup.....72a58c222fdd844e180571ca7a7cf35a