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A prognostic scoring model for survival after locoregional therapy in de novo stage IV breast cancer
- Source :
- Breast Cancer Research and Treatment. 170:677-685
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- The role of locoregional treatment (LRT) remains controversial in de novo stage IV breast cancer (BC). We sought to analyze the role of LRT and prognostic factors of overall survival (OS) in de novo stage IV BC patients treated with LRT utilizing the National Cancer Data Base (NCDB). The objective of the current study is to create and internally validate a prognostic scoring model to predict the long-term OS for de novo stage IV BC patients treated with LRT. We included de novo stage IV BC patients reported to NCDB between 2004 and 2015. Patients were divided into LRT and no-LRT subsets. We randomized LRT subset to training and validation cohorts. In the training cohort, a seventeen-point prognostic scoring system was developed based on the hazard ratios calculated using Cox-proportional method. We stratified both training and validation cohorts into two “groups” [group 1 (0–7 points) and group 2 (7–17 points)]. Kaplan–Meier method and log-rank test were used to compare OS between the two groups. Our prognostic score was validated internally by comparing the OS between the respective groups in both the training and validation cohorts. Among 67,978 patients, LRT subset (21,200) had better median OS as compared to that of no-LRT (45 vs. 24 months; p
- Subjects :
- Adult
0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Scoring system
Breast Neoplasms
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
medicine
Humans
Neoplasm Metastasis
Internal validation
Aged
Neoplasm Staging
Proportional Hazards Models
Aged, 80 and over
Models, Statistical
business.industry
Significant difference
Hazard ratio
Middle Aged
Prognosis
medicine.disease
Combined Modality Therapy
Survival Analysis
Training cohort
Survival Rate
030104 developmental biology
030220 oncology & carcinogenesis
Cohort
Female
Neoplasm Grading
Stage iv
business
Subjects
Details
- ISSN :
- 15737217 and 01676806
- Volume :
- 170
- Database :
- OpenAIRE
- Journal :
- Breast Cancer Research and Treatment
- Accession number :
- edsair.doi.dedup.....72a1947e63abbd09b90d07da7338564f