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Corrigendum to 'Benzene and childhood acute leukemia in Oklahoma'
- Source :
- Environmental research. 165
- Publication Year :
- 2018
-
Abstract
- Although childhood cancer is a leading cause of childhood mortality in the US, evidence regarding the etiology is lacking. The goal of this study was to evaluate the association between benzene, a known carcinogen, and childhood acute leukemia.We conducted a case-control study including cases diagnosed with acute leukemia between 1997 and 2012 (n = 307) from the Oklahoma Central Cancer Registry and controls matched on week of birth from birth certificates (n = 1013). We used conditional logistic regression to evaluate the association between benzene, measured with the 2005 National-Scale Air Toxics Assessment (NATA) at census tract of the birth residence, and childhood acute leukemia.We observed no differences in benzene exposure overall between cases and controls. However, when stratified by year of birth, cases born from 2005 to 2010 had a three-fold increased unadjusted odds of elevated exposure compared to controls born in this same time period (4th Quartile OR: 3.53, 95% CI: 1.35, 9.27). Furthermore, the estimates for children with acute myeloid leukemia (AML) were stronger than those with acute lymphoid leukemia, though not statistically significant.While we did not observe an association between benzene and childhood leukemia overall, our results suggest that acute leukemia is associated with increased benzene exposure among more recent births, and children with AML may have increased benzene exposure at birth. Using the NATA estimates allowed us to assess a specific pollutant at the census tract level, providing an advantage over monitor or point source data. Our study, however, cannot rule out the possibility that benzene may be a marker of other traffic-related exposures and temporal misclassification may explain the lack of an association among earlier births.
- Subjects :
- Male
medicine.medical_specialty
Adolescent
010501 environmental sciences
01 natural sciences
Biochemistry
Article
03 medical and health sciences
chemistry.chemical_compound
Young Adult
0302 clinical medicine
Odds Ratio
Medicine
Humans
030212 general & internal medicine
Benzene
Child
0105 earth and related environmental sciences
General Environmental Science
Acute leukemia
business.industry
Infant, Newborn
Infant
Oklahoma
Environmental Exposure
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Dermatology
Leukemia, Myeloid, Acute
Logistic Models
chemistry
Case-Control Studies
Child, Preschool
Environmental Pollutants
Female
business
Subjects
Details
- ISSN :
- 10960953
- Volume :
- 165
- Database :
- OpenAIRE
- Journal :
- Environmental research
- Accession number :
- edsair.doi.dedup.....7296892e1df4ab22450cfba8c35d2149