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Persistence profile to nucleos(t)ide analogue treatment for patients with chronic hepatitis B
- Source :
- European journal of hospital pharmacy : science and practice. 23(5)
- Publication Year :
- 2015
-
Abstract
- BACKGROUND: There are currently five approved nucleos(t)ide analogues (NUCs) for the management of chronic hepatitis B (CHB): lamivudine, adefovir dipivoxil, telbivudine, entecavir, and tenofovir disoproxil fumarate. OBJECTIVE: To determine the persistence rates among patients receiving NUCs for CHB at weeks 48, 96 and 144, compare them in these periods, and analyse the evolution of treatment persistence. METHODS: We conducted a retrospective study that included patients with CHB who initiated antiviral therapy and were attended to by the pharmaceutical care office between January 2002 and December 2011. Patients included in a clinical trial or patients who did not collect their medication personally were excluded. There were two different analyses: a comparative analysis of the persistence rates in three periods (weeks 1–48, weeks 48–96, and weeks 96–144); and a Kaplan-Meier analysis to evaluate the evolution of persistence. RESULTS: A total of 102 patients were included. Persistence rates were different in the three periods. They decreased during the course of the different periods, and the decline was more rapid between the first and second period. There were statistically significant differences in the non-persistence of the five drugs (p
- Subjects :
- medicine.medical_specialty
Long-term persistence
Outcomes
Phamaceutical care
030204 cardiovascular system & hematology
Persistence (computer science)
Persistence
Nucleotide analogues
03 medical and health sciences
0302 clinical medicine
Nucleoside analogues
Telbivudine
Internal medicine
medicine
Adefovir
030212 general & internal medicine
General Pharmacology, Toxicology and Pharmaceutics
Medication compliance
business.industry
Lamivudine
Retrospective cohort study
Entecavir
Hepatitis B
medicine.disease
Virology
Protease
Treatment
Clinical trial
Adherence
Original Article
Therapy
business
medicine.drug
Subjects
Details
- ISSN :
- 20479964
- Volume :
- 23
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- European journal of hospital pharmacy : science and practice
- Accession number :
- edsair.doi.dedup.....728f7d05b0cf14d087ec1ae2b984b284