Back to Search
Start Over
Indication of Thalamo-Cortical Circuit Dysfunction in Idiopathic Normal Pressure Hydrocephalus : A Tensor Imaging Study
- Source :
- Scientific Reports, Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
- Publication Year :
- 2020
- Publisher :
- Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, 2020.
-
Abstract
- Idiopathic normal pressure hydrocephalus (iNPH) is a disorder with unclear pathophysiology. The diagnosis of iNPH is challenging due to its radiological similarity with other neurodegenerative diseases and ischemic subcortical white matter changes. By using Diffusion Tensor Imaging (DTI) we explored differences in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in iNPH patients (before and after a shunt surgery) and healthy individuals (HI) and we correlated the clinical results with DTI parameters. Thirteen consecutive iNPH-patients underwent a pre- and post-operative clinical work-up: 10 m walk time (w10mt) steps (w10ms), TUG-time (TUGt) and steps (TUGs); for cognitive function MMSE. Nine HI were included. DTI was performed before and 3 months after surgery, HI underwent DTI once. DTI differences analyzed by manually placing 12 regions-of-interest. In patients motor and balance function improved significantly after surgery (p = 0.01, p = 0.025). Higher nearly significant FA values found in the patients vs HI pre-operatively in the thalamus (p = 0.07) accompanied by an almost significant lower ADC (p = 0.08). Significantly FA and ADC-values were found between patients and HI in FWM (p = 0.02, p = 0.001) and almost significant (p = 0.057) pre- vs postoperatively. Postoperatively we found a trend towards the HIs FA values and a strong significant negative correlation between FA changes vs. gait results in the FWM (r = −0.7, p = 0.008). Our study gives a clear indication of an ongoing pathological process in the periventricular white matter, especially in the thalamus and in the frontal white matter supporting the hypothesis of a shunt reversible thalamo-cortical circuit dysfunction in iNPH.
- Subjects :
- medicine.medical_specialty
Neurology
Neurologi
Science
Thalamus
Article
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Fluid dynamics
Internal medicine
Fractional anisotropy
medicine
Effective diffusion coefficient
Pathological
Multidisciplinary
business.industry
medicine.disease
Hydrocephalus
Cardiology
Medicine
business
030217 neurology & neurosurgery
Shunt (electrical)
Diffusion MRI
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scientific Reports, Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
- Accession number :
- edsair.doi.dedup.....727e326669c3569f92aa8370e5effd6a