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A Cu(<scp>ii</scp>) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights
- Source :
- ResearcherID
- Publication Year :
- 2017
- Publisher :
- Royal Society of Chemistry (RSC), 2017.
-
Abstract
- A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods. peer-reviewed
- Subjects :
- Models, Molecular
0301 basic medicine
18 KDA
Protein Conformation
BINDING-AFFINITY
In vitro cytotoxicity
Antineoplastic Agents
Catalysis
Mice
03 medical and health sciences
Receptors, GABA
Murine tumor
In vivo
Cell Line, Tumor
Organometallic Compounds
Materials Chemistry
Translocator protein
Animals
Humans
PERIPHERAL BENZODIAZEPINE-RECEPTOR
SELECTIVE LIGANDS
Molecular Targeted Therapy
SITES
biology
Chemistry
Metals and Alloys
General Chemistry
Xenograft Model Antitumor Assays
CANCER
In vitro
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Gene Expression Regulation, Neoplastic
MODEL
Multiple drug resistance
030104 developmental biology
Biochemistry
Cell culture
Ceramics and Composites
biology.protein
Target binding
Copper
TSPO
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....7265e2cb8785cb33017c6a1301032852