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Focal depth measurements of the vaginal wall: a new method to noninvasively quantify vaginal wall thickness in the diagnosis and treatment of vaginal atrophy
- Source :
- Menopause (New York, N.Y.), 23(8), 833-838. Lippincott Williams and Wilkins
- Publication Year :
- 2016
-
Abstract
- OBJECTIVE The aim of the study was to evaluate if vaginal focal depth measurement could be a noninvasive method to quantify vaginal wall thickness. METHODS Postmenopausal women undergoing topical estrogen therapy because of vaginal atrophy (VA) were recruited. VA was diagnosed based on the presence of symptoms and vaginal pH at least 5.5. The control group consisted of women above 40 years without VA. Focal depth measurements were performed before and after treatment using the Cytocam-Incident Dark Field device assessing the distance between the subepithelial microcirculation and the epithelial surface. Measurements were performed before and after treatment in the intervention group and at two different time points in the control group. Vaginal pH was measured. Symptoms were evaluated using the most bothersome symptom approach. RESULTS Eight women with VA and nine controls were included. Pretreatment median focal depth was not significantly different between both groups. Pretreatment focal depth more than doubled after a median of 7 weeks of topical estrogen treatment (80 μm [interquartile range 80-120 μm] vs 220 μm [148-248 μm], P = 0.02), whereas the measurements in the control group did not change. Pretreatment vaginal pH differed between both groups (5.5 vs 5.1, respectively, P
- Subjects :
- medicine.medical_specialty
medicine.drug_class
General Mathematics
Vaginal Diseases
030232 urology & nephrology
Urology
Vaginal wall
Urogynecology
03 medical and health sciences
0302 clinical medicine
Vaginal disease
Atrophy
Interquartile range
medicine
Humans
Diagnostic Techniques, Obstetrical and Gynecological
030219 obstetrics & reproductive medicine
business.industry
Applied Mathematics
Obstetrics and Gynecology
Estrogens
Hydrogen-Ion Concentration
Middle Aged
medicine.disease
Surgery
Administration, Intravaginal
medicine.anatomical_structure
Estrogen
Case-Control Studies
Vagina
Female
Vaginal atrophy
business
Subjects
Details
- Language :
- English
- ISSN :
- 10723714
- Volume :
- 23
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Menopause (New York, N.Y.)
- Accession number :
- edsair.doi.dedup.....7252b158384965d0fd2fa9ef49e11899