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Benign and Malignant Nodular Thyroid Disease in Acromegaly. Is a Routine Thyroid Ultrasound Evaluation Advisable?
- Source :
- Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, PLoS ONE, Repositorio Abierto de la UdL, Universitad de Lleida, PLoS ONE, Vol 9, Iss 8, p e104174 (2014), Recercat. Dipósit de la Recerca de Catalunya, instname, PLoS One, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
- Publication Year :
- 2014
-
Abstract
- Data on the prevalence of benign and malignant nodular thyroid disease in patients with acromegaly is a matter of debate. In the last decade an increasing incidence of thyroid cancer has been reported. The aim of this study was to evaluate the prevalence of goiter, thyroid nodules and thyroid cancer in a large series of patients with acromegaly with a cross-sectional study with a control group. Six Spanish university hospitals participated. One hundred and twenty three patients (50% men; mean age 59613 years; disease duration 6.767.2 years) and 50 controls (51% males, mean age 58615 years) were studied. All participants underwent thyroid ultrasound and fine needle aspiration. Cytological analysis was performed in suspicious nodules between 0.5 and 1.0 cm and in all nodules greater than 1.0 cm. Goiter was more frequently found in patients than in controls (24.9 vs. 8.3%, respectively; p,0.001). Nodular thyroid disease as well as nodules greater than 1 cm were also more prevalent in acromegalic patients (64.6%, vs. 28.6%, p,0.05 and 53.3 vs. 28.6%, respectively; p,0.05), and all underwent fine needle aspiration. Suspicious cytology was detected in 4 patients and in none of the controls. After thyroidectomy, papillary thyroid carcinoma was confirmed in two cases (3.3% of patients with thyroid nodules), representing 1.6% of the entire group of patients with acromegaly (2.4% including a case with previously diagnosed papillary thyroid carcinoma). These data indicated that thyroid nodular disease and cancer are increased in acromegaly, thus justifying its routine ultrasound screening.
- Subjects :
- Thyroid nodules
Male
medicine.medical_specialty
endocrine system
Goiter
endocrine system diseases
medicine.medical_treatment
Thyroid Imaging
Thyroid Gland
lcsh:Medicine
Carcinomas
Diagnostic Radiology
Thyroid carcinoma
Diagnosis, Differential
Endocrinology
Diagnostic Medicine
Acromegaly
medicine
Medicine and Health Sciences
Humans
Thyroid Neoplasms
Thyroid Nodule
lcsh:Science
Thyroid cancer
Aged
Ultrasonography
Gynecology
Multidisciplinary
medicine.diagnostic_test
business.industry
Radiology and Imaging
lcsh:R
Thyroid
Thyroidectomy
Cancers and Neoplasms
Organ Size
Middle Aged
medicine.disease
Fine-needle aspiration
medicine.anatomical_structure
Cross-Sectional Studies
Oncology
lcsh:Q
Female
Radiology
Thyroid Carcinomas
business
Research Article
Subjects
Details
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, PLoS ONE, Repositorio Abierto de la UdL, Universitad de Lleida, PLoS ONE, Vol 9, Iss 8, p e104174 (2014), Recercat. Dipósit de la Recerca de Catalunya, instname, PLoS One, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
- Accession number :
- edsair.doi.dedup.....724084b97bda49482927e6a6e6d2ea5f