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Verbal Working Memory and Atherosclerosis in Patients with Cardiovascular Disease: An fMRI study
- Source :
- Journal of Neuroimaging. 17:227-233
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- Background and Purpose. Intimal–medial thickening (IMT) of the carotid wall is an accepted peripheral marker of atherosclerosis. It is associated with increased risk for myocardial infarction and stroke, and lower attention-executive-psychomotor functioning. The purpose of this study was to examine the relationship between IMT and brain activity during a verbal working memory (VWM) task in patients with cardiovascular disease (CVD). Methods. Thirteen CVD patients underwent functional magnetic resonance imaging (fMRI) during a 2-Back VWM task, and B-mode ultrasound of the carotid arteries. IMT was calculated using an automated algorithm based on a validated edge-detection technique. The relationship between IMT and 2-Back-related brain activity was modeled using partial correlations controlling for age and small vessel disease as measured by white matter signal hyperintensities on MRI (WMH). Results. Higher IMT was associated with lower 2-Back-related signal intensity and in the right middle frontal gyrus, independent of age and WMH. Conclusions. IMT may be one mechanism contributing to brain dysfunction in CVD. The blood oxygenation level-dependent (BOLD) contrast appears to be highly sensitive to peripheral vascular health as measured by IMT. Future studies should examine the sensitivity and specificity of the BOLD response for predicting cognitive decline in CVD.
- Subjects :
- Carotid Artery Diseases
Male
medicine.medical_specialty
Pathology
Brain activity and meditation
Neuropsychological Tests
Sensitivity and Specificity
behavioral disciplines and activities
White matter
Internal medicine
Image Processing, Computer-Assisted
medicine
Humans
Radiology, Nuclear Medicine and imaging
Longitudinal Studies
cardiovascular diseases
Myocardial infarction
Cognitive decline
Stroke
Aged
Aged, 80 and over
medicine.diagnostic_test
business.industry
Working memory
Middle Aged
Verbal Learning
Atherosclerosis
medicine.disease
Magnetic Resonance Imaging
Hyperintensity
Memory, Short-Term
medicine.anatomical_structure
Pattern Recognition, Visual
cardiovascular system
Cardiology
Female
Neurology (clinical)
Functional magnetic resonance imaging
business
Algorithms
Psychomotor Performance
Subjects
Details
- ISSN :
- 15526569 and 10512284
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroimaging
- Accession number :
- edsair.doi.dedup.....7234ff96dd0ca80967e184bd2c05cd8c