The role of the disintegrin-metalloprotease ADAM8 in high-grade gliomas

Authors :: Schlomann, U
Schulz, W
Schieber, S
Conrad, C
Dong, F
Pagenstecher, A
Bartsch, JW
Nimsky, C
Source :: 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); 20130526-20130529; Düsseldorf; DOCDI.09.01 /20130521/
Publication Year :: 2013
Publisher :: German Medical Science GMS Publishing House, 2013.
Abstract: Objective: ADAM proteases are important mediators of tumor growth, invasion and angiogenesis. As such, ADAM8 is of clinical significance, since glioma patient survival correlates inversely with ADAM8 expression levels. In this respect we hypothesised that ADAM8 has a therapeutic window in high-grade[for full text, please go to the a.m. URL]<br />64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Subjects :: Metalloprotease
ddc: 610
Glioma
Angiogenesis
610 Medical sciences
Medicine

Language :: English
Database :: OpenAIRE
Journal :: 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); 20130526-20130529; Düsseldorf; DOCDI.09.01 /20130521/
Accession number :: edsair.doi.dedup.....723483c82afe3cc51e90f20a4e4bf58c
Full Text :: https://doi.org/10.3205/13dgnc239