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Stilbene-based anticancer agents: Resveratrol analogues active toward HL60 leukemic cells wit a non-specific phase mechanism
- Publication Year :
- 2006
-
Abstract
- Several stilbenes, related to known resveratrol, have been synthesized and tested for their anticancer effect on HL60 leukemia cell line, taking particular care of the cell cycle analysis. The most potent compound was the known (Z)-3,4',5-trimethoxystilbene (6b) which was active as apoptotic agent at 0.24 microM. Differently from other stilbenes (including resveratrol) that induced a prevalent recruitment of cells in S phase of cell cycle, we found a peculiar behavior of 6b that caused a decrease of cells in all phases of cell cycle (G0-G1, S, and G2-M) and a proportional increase of apoptotic cells. The potent pro-apoptotic activity shown by compound 6b and its effects on cell cycle make this compound of great interest for further investigations.
- Subjects :
- Antimony
HL60
Clinical Biochemistry
Pharmaceutical Science
Antineoplastic Agents
HL-60 Cells
Resveratrol
Biochemistry
Structure-Activity Relationship
chemistry.chemical_compound
Stilbenes
Drug Discovery
medicine
Humans
Structure–activity relationship
Molecular Biology
S phase
Cell Proliferation
Molecular Structure
Organic Chemistry
Cell cycle
Mechanism of action
chemistry
Anticancer agent
Cell culture
Apoptosis
Resveratrol analogue
Cell cycle analysis
Molecular Medicine
medicine.symptom
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....722d6f0feb0109efce9f926592c93d3f