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Interstitial and Granulomatous Lung Disease in Inflammatory Bowel Disease Patients
- Source :
- Journal of Crohn's and Colitis, 14, 4, pp. 480-489, Journal of Crohn's & colitis, Vol. 14, no. 4, p. 480-489 (2020), Journal of Crohn's and Colitis, 14, 480-489, JOURNAL OF CROHNS & COLITIS, r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol, instname
- Publication Year :
- 2020
-
Abstract
- Background Interstitial lung [ILD] disease and granulomatous lung disease [GLD] are rare respiratory disorders that have been associated with inflammatory bowel disease [IBD]. Clinical presentation is polymorphic and aetiology is unclear. Methods This was an ECCO-CONFER project. Cases of concomitant ILD or GLD and IBD, or drug-induced ILD/GLD, were collected. The criteria for diagnosing ILD and GLD were based on definitions from the American Thoracic Society and the European Respiratory Society and on the discretion of reporting clinician. Results We identified 31 patients with ILD. The majority had ulcerative colitis [UC] [n = 22]. Drug-related ILD was found in 64% of these patients, 25 patients [80.6%] required hospitalisation, and one required non-invasive ventilation. The causative drug was stopped in all drug-related ILD, and 87% of patients received systemic steroids. At follow-up, 16% of patients had no respiratory symptoms, 16% had partial improvement, 55% had ongoing symptoms, and there were no data in 13%. One patient was referred for lung transplantation, and one death from lung fibrosis was reported. We also identified 22 GLD patients: most had Crohn’s disease [CD] [n = 17]. Drug-related GLD was found in 36% of patients and 10 patients [45.4%] required hospitalisation. The causative drug was stopped in all drug-related GLD, and 81% of patients received systemic steroids. Remission of both conditions was achieved in almost all patients. Conclusions ILD and GLD, although rare, can cause significant morbidity. In our series, over half of cases were drug-related and therefore focused pharmacovigilance is needed to identify and manage these cases.
- Subjects :
- Male
medicine.medical_specialty
Drug-Related Side Effects and Adverse Reactions
medicine.medical_treatment
Anti-Inflammatory Agents
Comorbidity
Disease
Global Health
Inflammatory bowel disease
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Lung transplantation
030212 general & internal medicine
Glucocorticoids
Lung
business.industry
General Medicine
Middle Aged
respiratory system
Inflammatory Bowel Diseases
medicine.disease
Ulcerative colitis
respiratory tract diseases
Hospitalization
Pneumonia
Outcome and Process Assessment, Health Care
medicine.anatomical_structure
Etiology
Female
030211 gastroenterology & hepatology
Symptom Assessment
Lung Diseases, Interstitial
business
Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5]
Lung Transplantation
Subjects
Details
- ISSN :
- 18739946
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of Crohn's and Colitis
- Accession number :
- edsair.doi.dedup.....7220d97b6125edaef5451da81766efca