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Cytokine gene polymorphisms and sudden infant death syndrome
- Source :
- Acta paediatrica (Oslo, Norway : 1992). 99(3)
- Publication Year :
- 2009
-
Abstract
- Aim: Several studies indicate that the mucosal immune system is stimulated in cases of sudden infant death syndrome (SIDS), and our hypothesis is that this immune reaction is because of an unfavourable combination of functional polymorphisms in the cytokine genes. Methods: Thus, in this study, single nucleotide polymorphisms (SNPs) in the genes encoding IL-6, IL-8, IL-12, IL-13, IL-16, IL-18 and IFNγ were investigated in 148 SIDS cases, 56 borderline SIDS cases, 41 cases of infectious death and 131 controls. Results: Regarding genotype distribution, no differences between the investigated groups were found. However, in the SIDS group, the genotypes IL-8 −251AA/AT and IL-8 −781CT/TT were significantly more frequent in the SIDS cases found dead in a prone sleeping position, compared with SIDS cases found dead in other sleeping positions. In addition, there was an association between fever prior to death and the genotype IL-13 +4464GG in the cases of infectious death. Conclusion: This study indicates that specific interleukin genotypes are a part of a genetic make up that make infants sleeping prone at risk for SIDS.
- Subjects :
- Male
Genotype
Single-nucleotide polymorphism
Sudden death
Polymorphism, Single Nucleotide
Interferon-gamma
Risk Factors
Prone Position
Medicine
Humans
Genetic Predisposition to Disease
Allele
Interleukin 6
biology
business.industry
Interleukins
Haplotype
Infant
General Medicine
Sudden infant death syndrome
Case-Control Studies
Pediatrics, Perinatology and Child Health
Immunology
biology.protein
Interleukin 18
Female
business
Sleep
Sudden Infant Death
Subjects
Details
- ISSN :
- 16512227
- Volume :
- 99
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Acta paediatrica (Oslo, Norway : 1992)
- Accession number :
- edsair.doi.dedup.....721920cb2bcb408ba90042693a58d120