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Antilipidemic effects and gene expression profiling of the glycosaminoglycans from cricket in rats on a high fat diet
- Source :
- Archives of Pharmacal Research. 39:926-936
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Glycosaminoglycan (GAG) from cricket (Gryllus bimaculatus) was studied as a potential health supplement. Antiatherosclerotic and antilipidemic effects of the GAG of G. bimaculatus (GbG, 5 or 10 mg/kg) were investigated in 15-week old Wistar rats treated with GbG for over a month. GbG produced a meaningful anti-edema effect with inhibition of C-reactive protein (CRP). Also, the weights of abdominal and epididymidal fat were also reduced in conjunction with a mild increase in body weight. Furthermore, the sero-biochemical parameters showed an antihyperlipidemic effect with decreased levels of phospholipid, AST, ALT, total cholesterol and glucose in a dose-dependent manner. In addition anticoagulant and antithrombotic effects were seen: platelet, thrombin time, prothrombin time and Factor I were increased with GbG treatment. Furthermore, the GbG treated rat group (at 10 mg/kg) compared to control, showed that 588 genes (test/control ratio >2.0) including lipocalin 2 (Lcn2) and alpha 2-macroglobulin (A2 m) were up-regulated, and 569 genes (test/control ratio >0.5) including stearoyl-coenzyme A desaturase 1 (Scd1) were down-regulated. Based on these results, GbG could potentially prevent or treat fatty liver or hyperlipidemia in rats on a high-fat diet.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Alpha (ethology)
Complement factor I
Lipocalin
Thrombin time
Diet, High-Fat
Gryllidae
Glycosaminoglycan
03 medical and health sciences
0302 clinical medicine
Internal medicine
Drug Discovery
Hyperlipidemia
medicine
Animals
Rats, Wistar
Glycosaminoglycans
Hypolipidemic Agents
biology
medicine.diagnostic_test
Gene Expression Profiling
Gryllus bimaculatus
Body Weight
Fatty Acids
Organic Chemistry
Fatty liver
biology.organism_classification
medicine.disease
Rats
030104 developmental biology
Endocrinology
Adipose Tissue
030220 oncology & carcinogenesis
Molecular Medicine
Subjects
Details
- ISSN :
- 19763786 and 02536269
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Archives of Pharmacal Research
- Accession number :
- edsair.doi.dedup.....7214596c7397896a1d526adbc71fcbb5