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Transmission networks of HIV-1 among men having sex with men in the Netherlands

Authors :: Bezemer, Daniela
van Sighem, Ard
Lukashov, Vladimir V.
van der Hoek, Lia
Back, Nicole
Schuurman, Rob
Boucher, Charles A. B.
Claas, Eric C. J.
Boerlijst, Maarten C.
Coutinho, Roel A.
de Wolf, Frank
Prins, J. M.
Bos, J. C.
Eeftinck-Schattenkerk, J. K. M.
Geerlings, S. E.
Godfried, M. H.
Lange, J. M. A.
van der Meer, J. T. M.
Nellen, F. J. B.
Olszyna, D. P.
van der Poll, T.
Reiss, P.
Sankatsing, S. U. C.
Steingrover, R.
van der Valk, M.
Vermeulen, J. N.
Vrouenraets, S. M. E.
van Vugt, M.
Schrei, G.
van der Geest, S.
Oude Lashof, A.
Lowe, S.
Verbon, A.
Bravenboer, B.
Pronk, M. J. H.
Kuijpers, T. W.
Pajkrt, D.
Scherpbier, H. J.
van der Ende, M. E.
Bax, H.
van der Feltz, M.
Gelinck, L. B. S.
de Melo, Mendoca
Nouwen, J. L.
Rijnders, B. J. A.
de Ruiter, E. D.
Zaaijer, H. L.
Berkhout, B.
Jurriaans, S.
van Kan, H. J. M.
Bakker, Margreet
Theoretical Ecology (IBED, FNWI)
Faculteit der Geneeskunde
Medical Informatics
Virology
Amsterdam institute for Infection and Immunity
Amsterdam Public Health
Medical Microbiology and Infection Prevention
Infectious diseases
Other departments
Graduate School
General Internal Medicine
Paediatric Infectious Diseases / Rheumatology / Immunology
Source :: AIDS, 24(2), 271-282, AIDS, 24(2), 271-282. Lippincott Williams & Wilkins, Aids, 24, 2, pp. 271-82, Aids, 24, 271-82, AIDS, 24, 271-282. Lippincott Williams & Wilkins, AIDS (London, England), 24(2), 271-282. Lippincott Williams and Wilkins
Publication Year :: 2010
Publisher :: Lippincott Williams & Wilkins, 2010.
Abstract: Contains fulltext : 87614.pdf (Publisher’s version ) (Closed access) OBJECTIVE: To obtain insight in the HIV-1 transmission networks among men having sex with men (MSM) in the Netherlands. DESIGN: A phylogenetic tree was constructed from polymerase sequences isolated from 2877 HIV-1 subtype B-infected patients monitored as part of the AIDS Therapy Evaluation in the Netherlands (ATHENA) nationwide observational cohort. METHODS: For MSM with a known date of infection, the most similar sequences were selected as potential transmission pairs when they clustered with bootstrap value of at least 99%. Time from infection to onward transmission was estimated as the median time between dates of infection for each transmission pair. The source of infections with a resistant strain was traced using the entire phylogenetic tree. RESULTS: Of sequences from 403 MSM with a known date of infection between 1987 and 2007, 175 (43%) formed 63 clusters. Median time to onward transmission was 1.4 years (interquartile range 0.6-2.7). Twenty-four (6%) MSM carried a virus with resistance-related mutations, 13 of these were in eight clusters together with sequences from 28 other patients in the entire phylogenetic tree. Six clusters contained sequences obtained from 29 men all presenting the same resistance-related mutations. CONCLUSION: From our selection of likely transmission pairs, we conclude that onward transmission of HIV-1 from infected MSM in the Netherlands happens both during and after primary infection. Transmission of resistant strains from the antiretroviral therapy-treated population is limited, but strains with resistance-related mutations have formed subepidemics.