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Long-term results of therapy with mycophenolate mofetil in chronic non-infectious uveitis
- Source :
- Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 249(8)
- Publication Year :
- 2011
-
Abstract
- Short-term studies have shown mycophenolate mofetil (MMF) to be a useful immunosuppressive agent for the treatment of intraocular inflammation. The aim of our study was to assess the long-term efficacy and tolerability of MMF in patients with chronic non-infectious uveitis, as well as to analyze disease course following discontinuation of therapy. This is a retrospective case series on 60 uveitis patients treated with MMF with a follow-up period of at least 5 years. The main outcome measures were: control of inflammation, corticosteroid-sparing potential, side-effects, ability to stop/taper MMF treatment because of effective control of inflammation and relapse rate after therapy discontinuation. Control of intraocular inflammation (efficacy of MMF), defined as inactive disease under prednisolone dose of ≤10 mg daily, was achieved in 43 of 60 patients (72%) after 1 year of MMF treatment at a rate of 0.72 per patient-year (PY), and in 45 of 55 patients (82%) after 2 years therapy (rate: 0.41/PY). An improvement (3 lines) or stabilization of visual acuity was observed in 49 patients (82%), and a worsening in 11 patients (18%, 95% CI: 10–30%). The probability of discontinuing prednisolone, estimated by the Kaplan–Meier method, was 40% after 5 years therapy. The probability of discontinuing mycophenolate mofetil due to efficacy was 33% after 5 years treatment. Recurrences of uveitis occurred in six of 21 patients (29%, rate: 0.11/PY) after MMF discontinuation due to efficacy. The treatment was stopped because of inefficacy in 12 patients (rate: 0.05/PY) and because of side-effects in four patients (rate: 0.02/PY). The rate of adverse effects during MMF therapy was 0.17/PY. Our data show that mycophenolate mofetil is generally effective and well tolerated in the treatment of chronic non-infectious uveitis.
- Subjects :
- Adult
Male
medicine.medical_specialty
Visual acuity
Adolescent
Visual Acuity
Mycophenolate
Gastroenterology
Uveitis
Cellular and Molecular Neuroscience
Young Adult
Recurrence
Internal medicine
medicine
Humans
Adverse effect
Child
Aged
Retrospective Studies
business.industry
Anti-Inflammatory Agents, Non-Steroidal
Retrospective cohort study
Middle Aged
Mycophenolic Acid
medicine.disease
Sensory Systems
Discontinuation
Ophthalmology
Treatment Outcome
Tolerability
Chronic Disease
Prednisolone
Female
medicine.symptom
business
Immunosuppressive Agents
medicine.drug
Follow-Up Studies
Subjects
Details
- ISSN :
- 1435702X
- Volume :
- 249
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
- Accession number :
- edsair.doi.dedup.....720bbc3fb234d49383b5943c2809788a