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Palladium(II)‐Initiated Catellani‐Type Reactions
- Source :
- Angewandte Chemie. 131:5890-5902
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- The Catellani reaction is known as a powerful strategy for the expeditious synthesis of highly substituted arenes and benzo-fused rings, which are usually difficult to access through traditional cross-coupling strategies. It utilizes the synergistic interplay of palladium and norbornene catalysis to facilitate sequential ortho C-H functionalization and ipso termination of aryl halides in a single operation. In classical Catellani-type reactions, aryl halides are mainly used as the substrates, and a Pd0 catalyst is required to initiate the reaction. Nevertheless, recent advances showcase that Catellani-type reactions can also be initiated by a PdII catalyst with different starting materials instead of aryl halides via different reaction mechanisms and under different conditions. This emerging concept of PdII /norbornene cooperative catalysis has significantly advanced Catellani-type reactions, thus enabling future developments of this field. In this Minireview, PdII -initiated Catellani-type reactions and their application in the synthesis of bioactive molecules are summarized.
- Subjects :
- Reaction mechanism
010405 organic chemistry
Bioactive molecules
Aryl
chemistry.chemical_element
Halide
General Chemistry
General Medicine
010402 general chemistry
01 natural sciences
Combinatorial chemistry
Catalysis
0104 chemical sciences
chemistry.chemical_compound
chemistry
Catellani reaction
Palladium
Norbornene
Subjects
Details
- ISSN :
- 15213757 and 00448249
- Volume :
- 131
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie
- Accession number :
- edsair.doi.dedup.....720400616b1b5bcdaaf09ecfa97c8bd5