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Palladium(II)‐Initiated Catellani‐Type Reactions

Authors :
Ruiming Chen
Hong-Gang Cheng
Qianghui Zhou
Shuqing Chen
Source :
Angewandte Chemie. 131:5890-5902
Publication Year :
2019
Publisher :
Wiley, 2019.

Abstract

The Catellani reaction is known as a powerful strategy for the expeditious synthesis of highly substituted arenes and benzo-fused rings, which are usually difficult to access through traditional cross-coupling strategies. It utilizes the synergistic interplay of palladium and norbornene catalysis to facilitate sequential ortho C-H functionalization and ipso termination of aryl halides in a single operation. In classical Catellani-type reactions, aryl halides are mainly used as the substrates, and a Pd0 catalyst is required to initiate the reaction. Nevertheless, recent advances showcase that Catellani-type reactions can also be initiated by a PdII catalyst with different starting materials instead of aryl halides via different reaction mechanisms and under different conditions. This emerging concept of PdII /norbornene cooperative catalysis has significantly advanced Catellani-type reactions, thus enabling future developments of this field. In this Minireview, PdII -initiated Catellani-type reactions and their application in the synthesis of bioactive molecules are summarized.

Details

ISSN :
15213757 and 00448249
Volume :
131
Database :
OpenAIRE
Journal :
Angewandte Chemie
Accession number :
edsair.doi.dedup.....720400616b1b5bcdaaf09ecfa97c8bd5