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Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome
- Source :
- Case Reports in Transplantation, Case Reports in Transplantation, Vol 2014 (2014), Craig, D G, Lee, P, Pryde, E A, Hidalgo, E, Hayes, P C, Wigmore, S J, Forbes, S J & Simpson, K J 2014, ' Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome ' vol. 2014, pp. 272498 . DOI: 10.1155/2014/272498
- Publication Year :
- 2014
- Publisher :
- Hindawi Limited, 2014.
-
Abstract
- Background. Small-for-size syndrome (SFSS) occurs in the presence of insufficient liver mass to maintain normal function after liver transplantation. Murine mortality following 85% hepatectomy can be reduced by the use of soluble receptor for advanced glycation end products (sRAGE) to scavenge damage-associated molecular patterns and prevent their engagement with membrane-bound RAGE.Aims. To explore serum levels of sRAGE, high-mobility group box-1 (HMGB1) protein, and other soluble inflammatory mediators in a fatal case of SFSS.Methods. Serum levels of HMGB1, sRAGE, IL-18, and other inflammatory mediators were measured by ELISA in a case of SFSS, and the results were compared with 8 patients with paracetamol-induced acute liver failure (ALF) and 6 healthy controls (HC).Results. HMGB1 levels were markedly higher in the SFSS patient (92.1 ng/mL) compared with the ALF patients (median (IQR) 11.4 (3.7–14.8) ng/mL) and HC (1.42 (1.38–1.56) ng/mL). In contrast, sRAGE levels were lower in the SFSS patient (1.88 ng/mL) compared with the ALF patients (3.53 (2.66–12.37) ng/mL) and were similar to HC levels (1.40 (1.23–1.89) ng/mL).Conclusion. These results suggest an imbalance between pro- and anti-inflammatory innate immune pathways in SFSS. Modulation of the HMGB1-RAGE axis may represent a future therapeutic avenue in this condition.
- Subjects :
- Small for size syndrome
medicine.medical_specialty
biology
business.industry
medicine.medical_treatment
lcsh:Surgery
Case Report
lcsh:RD1-811
Liver transplantation
HMGB1
Gastroenterology
Liver mass
High-mobility group
Glycation
Management of Technology and Innovation
Internal medicine
Immunology
biology.protein
Medicine
Hepatectomy
business
Receptor
Subjects
Details
- ISSN :
- 20906951 and 20906943
- Volume :
- 2014
- Database :
- OpenAIRE
- Journal :
- Case Reports in Transplantation
- Accession number :
- edsair.doi.dedup.....7200c2fa906466723e7fb7f75a26e33c