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Brucea javanica oil emulsion alleviates cachexia induced by Lewis lung cancer cells in mice
- Source :
- Journal of Drug Targeting. 26:222-230
- Publication Year :
- 2017
- Publisher :
- Informa UK Limited, 2017.
-
Abstract
- This study was conducted to evaluate the efficacy and possible mechanism of Brucea javanica oil emulsion (BJOE) on cachexia, by observing changes in related indexes in mice with cachexia and identifying the genes responsible based on gene chip analysis. In the BJOE treatment group, body weight loss, tumour growth and metastasis were found obviously inhibited, food and water intake had markedly increased, and survival time was significantly prolonged, as compared to the control group. Moreover, the BJOE witnessed improvement in body weight, prevention of tumour metastasis and overall increase in survival time, as compared to Indometacin (IND, the positive control medicine). It was also found that TNF-α and IL-6 in serum were significantly lower in both groups of BJOE and IND, than in the control group (p .01). Based on the gene expression data, seven and six hub genes of BJOE and IND groups were found in the potential prognostic impacts networks, and three common genes comprising of Nmd3, Bcl2 and Nhp2l1 were screened. Thus, BJOE could reduce tumour growth and effectively alleviate cancer cachexia, due to inhibition of pro-inflammatory cytokines. Nmd3, Bcl2, Nhp2l1 may be important drug targets, establishing the role of BJOE in the treatment of lung cancer induced cachexia.
- Subjects :
- Male
0301 basic medicine
Hub genes
Cachexia
ved/biology.organism_classification_rank.species
Pharmaceutical Science
Pharmacology
Metastasis
Carcinoma, Lewis Lung
Eating
Mice
Random Allocation
03 medical and health sciences
0302 clinical medicine
Indometacin
Gene expression
Brucea
medicine
Animals
Plant Oils
Lung cancer
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
ved/biology
Body Weight
RNA-Binding Proteins
Ribonucleoproteins, Small Nuclear
medicine.disease
Oil emulsion
Mice, Inbred C57BL
030104 developmental biology
Brucea javanica
Proto-Oncogene Proteins c-bcl-2
030220 oncology & carcinogenesis
Immunology
Emulsions
business
medicine.drug
Subjects
Details
- ISSN :
- 10292330 and 1061186X
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Journal of Drug Targeting
- Accession number :
- edsair.doi.dedup.....71fa575999a5d5992ca5255662002c75
- Full Text :
- https://doi.org/10.1080/1061186x.2017.1354003