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Preparation of nano/macroporous polycaprolactone microspheres for an injectable cell delivery system using room temperature ionic liquid and camphene
- Source :
- Journal of Colloid and Interface Science. 465:18-25
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- The nano/macroporous polycaprolactone (PCL) microspheres with cell active surfaces were developed as an injectable cell delivery system. Room temperature ionic liquid (RTIL) and camphene were used as a liquid mold and a porogen, respectively. Various-sized spheres of 244-601μm with pores of various size and shape of 0.02-100μm, were formed depending on the camphene/RTIL ratio (0.8-2.6). To give cell activity, the surface of porous microspheres were further modified with nerve growth factors (NGF) containing gelatin to give a thin NGF/gelatin layer, to which the neural progenitor cells (PC-12) attached and extended their neurites on to the surface layers of the microspheres. The developed microspheres may be potentially applicable as a neuronal cell delivery scaffold for neuron tissue engineering.
- Subjects :
- Materials science
food.ingredient
Polyesters
Ionic Liquids
02 engineering and technology
010402 general chemistry
PC12 Cells
01 natural sciences
Gelatin
Biomaterials
Nanopores
chemistry.chemical_compound
Colloid and Surface Chemistry
food
Neural Stem Cells
Tissue engineering
Nerve Growth Factor
Nano
Animals
Bicyclic Monoterpenes
Terpenes
021001 nanoscience & nanotechnology
Microspheres
Rats
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Polyester
Nanopore
chemistry
Chemical engineering
Ionic liquid
Polycaprolactone
Camphene
0210 nano-technology
Subjects
Details
- ISSN :
- 00219797
- Volume :
- 465
- Database :
- OpenAIRE
- Journal :
- Journal of Colloid and Interface Science
- Accession number :
- edsair.doi.dedup.....71f8d6400fffc6ba80ceb4f34c6b1e3d