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Assessment of Long-term Changes in Lower Urinary Tract Symptoms in Patients With Prostate Cancer Who Underwent Low-dose-rate Prostate Brachytherapy
- Source :
- Urology. 142:213-220
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- OBJECTIVE To investigate long-term changes in lower urinary tract symptoms (LUTS) in patients with prostate cancer (PC) who underwent low-dose-rate brachytherapy with iodine-125 (LDR-BT). PATIENTS AND METHODS In this retrospective study, 313 patients with localized PC underwent LDR-BT at Gifu University hospital between August 2004 and December 2013. The International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS), and quality of life due to urinary symptoms (IPSS-QOL) were measured before LDR-BT; at 1, 3, 6, 9, 12, 24, 36, 48, and 60 months after LDR-BT; and annually thereafter. Study endpoints were chronological changes in IPSS, OABSS, and IPSS-QOL compared to pretreatment values. A multivariable non-linear regression model with robust sandwich estimator evaluated association between outcomes and time with adjustment for covariates. RESULTS All scores worsened immediately after LDR-BT compared to preoperative scores. However, symptoms improved with time and returned to baseline in 18–36 months. After a 5-year follow-up after LDR-BT, OABSS significantly worsened in almost all patients compared to baseline although there were gradual improvements in less than 5 years after LDR-BT. CONCLUSIONS Our results may be of clinical importance in selecting treatment modalities for patients with localized PC and long-term survival after definitive therapy.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Urology
medicine.medical_treatment
Brachytherapy
030232 urology & nephrology
Iodine Radioisotopes
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Lower Urinary Tract Symptoms
Lower urinary tract symptoms
medicine
Clinical endpoint
Humans
Aged
Retrospective Studies
business.industry
Prostatic Neoplasms
Radiotherapy Dosage
Retrospective cohort study
Middle Aged
medicine.disease
Overactive bladder
030220 oncology & carcinogenesis
International Prostate Symptom Score
business
Prostate brachytherapy
Subjects
Details
- ISSN :
- 00904295
- Volume :
- 142
- Database :
- OpenAIRE
- Journal :
- Urology
- Accession number :
- edsair.doi.dedup.....71f2f9154aa3624288b51a56fe988715