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Resting Pd/Pa correlates with fractional flow reserve but not angiographic severity in calcified coronary arteries
- Source :
- Catheterization and Cardiovascular Interventions. 97:625-631
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- OBJECTIVE Study the effect of coronary artery calcium (CAC) on resting coronary physiological indices. BACKGROUND Prior studies found no correlation between angiographic stenosis and fractional flow reserve (FFR) in heavily calcified arteries. METHODS Two hundred consecutive patients undergoing whole-cycle resting Pd/Pa and FFR evaluation of a single lesion of intermediate severity (40-80%) had CAC quantified based upon radiopacities at the site of the stenosis, where 0 = none or mild calcium, 1 = moderate calcium, and 2 = severe calcium. RESULTS Mean age was 61 ± 11 years and 34% were female. The mean degree of stenosis, FFR, and resting Pd/Pa were 60 ± 12%, 0.83 ± 0.08, and 0.93 ± 0.05, respectively. Resting Pd/Pa correlated with degree of angiographic diameter stenosis (DS) as determined by quantitative coronary angiography (QCA) or visual estimation in arteries with calcium score of 0 or 1, but there was no correlation in severely calcified arteries. The diagnostic accuracy of DS ≥70% by QCA to predict hemodynamic significance was 68% with calcium scores of 0/1, but only 43% with calcium score = 2. Resting Pd/Pa was highly correlated with FFR irrespective of the degree of CAC (R2 = 0.68, p
- Subjects :
- medicine.medical_specialty
Hemodynamics
chemistry.chemical_element
Diagnostic accuracy
Fractional flow reserve
030204 cardiovascular system & hematology
Calcium
Severity of Illness Index
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
030212 general & internal medicine
business.industry
Coronary Stenosis
General Medicine
medicine.disease
Coronary Vessels
Fractional Flow Reserve, Myocardial
Coronary arteries
Stenosis
Treatment Outcome
medicine.anatomical_structure
chemistry
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Artery
Subjects
Details
- ISSN :
- 1522726X and 15221946
- Volume :
- 97
- Database :
- OpenAIRE
- Journal :
- Catheterization and Cardiovascular Interventions
- Accession number :
- edsair.doi.dedup.....71ef95857a64cf405348311be9d0d07e