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The metastatic suppressor NDRG1 inhibits EMT, migration and invasion through interaction and promotion of caveolin-1 ubiquitylation in human colorectal cancer cells

Authors :
Minhua Zheng
Feng Zhu
Xiaokang Yang
L Mi
Y Zheng
Ming-Liang Wang
X Wen
Ai-Guo Lu
Jiaoyang Lu
Jiafu Ji
Jingchun Sun
Qiwu Zhao
Source :
Oncogene
Publication Year :
2016

Abstract

N-myc downstream-regulated gene 1 (NDRG1) has been reported to act as a key regulatory molecule in tumor progression-related signaling pathways, especially in tumor metastasis. However, the related mechanism has not been fully discovered yet. Herein we demonstrated that the novel molecule of cell migration and invasion, caveolin-1, has direct interaction with NDRG1 in human colorectal cancer (CRC) cells. Moreover, we discovered that NDRG1 reduces caveolin-1 protein expression through promoting its ubiquitylation and subsequent degradation via the proteasome in CRC cells. In addition, caveolin-1 mediates the suppressive function of NDRG1 in epithelial–mesenchymal transition, migration and invasion in vitro and metastasis in vivo. These results help to fulfill the potential mechanisms of NDRG1 in anti-metastatic treatment for human colorectal cancer.

Details

ISSN :
14765594
Volume :
36
Issue :
30
Database :
OpenAIRE
Journal :
Oncogene
Accession number :
edsair.doi.dedup.....71ebc997d72a23b752d5709b96ccf6fc