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Association of Female Genital Schistosomiasis With the Cervicovaginal Microbiota and Sexually Transmitted Infections in Zambian Women
- Source :
- Open Forum Infectious Diseases, OPEN FORUM INFECTIOUS DISEASES, Open Forum Infectious Diseases, 8(9). OXFORD UNIV PRESS INC
- Publication Year :
- 2021
- Publisher :
- Oxford University Press, 2021.
-
Abstract
- Background The cervicovaginal microbiota, including sexually transmitted infections (STIs), have not been well described in female genital schistosomiasis (FGS). Methods Women (aged 18–31, sexually active, nonpregnant) were invited to participate at the final follow-up of the HPTN 071 (PopART) Population Cohort in January–August 2018. We measured key species of the cervicovaginal microbiota (Lactobacillus crispatus, L. iners, Gardnerella vaginalis, Atopobium vaginae, and Candida) and STIs (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium) using quantitative PCR (qPCR). We evaluated associations of the microbiota and STI presence and concentration with FGS (qPCR-detected Schistosoma DNA in any of 3 genital specimens). Results The presence and concentration of key cervicovaginal species did not differ between participants with (n = 30) or without FGS (n = 158). A higher proportion of participants with FGS had T. vaginalis compared with FGS-negative women (P = .08), with further analysis showing that T. vaginalis was more prevalent among women with ≥2 Schistosoma qPCR-positive genital specimens (50.0%, 8/16) than among FGS-negative women (21.5%, 34/158; P = .01). Conclusions We found weak evidence of an association between the presence of T. vaginalis and FGS, with a stronger association in women with a higher-burden FGS infection. Additional research is needed on potential between-parasite interactions, especially regarding HIV-1 vulnerability.
- Subjects :
- POLYMERASE-CHAIN-REACTION
Physiology
Atopobium vaginae
medicine.disease_cause
Major Articles
female genital schistosomiasis
medicine
Medicine and Health Sciences
Gardnerella vaginalis
sexually transmitted infection
cervicovaginal microbiota
TRICHOMONAS-VAGINALIS
Schistosoma haematobium
UROGENITAL SCHISTOSOMIASIS
Lactobacillus crispatus
biology
business.industry
ACQUISITION
HIV
URINE SAMPLES
biology.organism_classification
HAEMATOBIUM INFECTION
Infectious Diseases
MANIFESTATIONS
AcademicSubjects/MED00290
Oncology
BACTERIAL VAGINOSIS
Neisseria gonorrhoeae
INNATE IMMUNITY
Trichomonas vaginalis
Chlamydia trachomatis
business
Mycoplasma genitalium
Subjects
Details
- Language :
- English
- ISSN :
- 23288957
- Volume :
- 8
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Open Forum Infectious Diseases
- Accession number :
- edsair.doi.dedup.....71d1d3fc8217bc8a5a42ee1b4f59876c