Back to Search
Start Over
Bacterial sensing via neuronal Nod2 regulates appetite and body temperature
- Source :
- Science, Science, 2022, 376 (6590), pp.eabj3986. ⟨10.1126/science.abj3986⟩
- Publication Year :
- 2022
- Publisher :
- HAL CCSD, 2022.
-
Abstract
- International audience; Gut bacteria influence brain functions and metabolism. We investigated whether this influence can be mediated by direct sensing of bacterial cell wall components by brain neurons. In mice, we found that bacterial peptidoglycan plays a major role in mediating gut-brain communication via the Nod2 receptor. Peptidoglycan-derived muropeptides reach the brain and alter the activity of a subset of brain neurons that express Nod2. Activation of Nod2 in hypothalamic inhibitory neurons is essential for proper appetite and body temperature control, primarily in females. This study identifies a microbe-sensing mechanism that regulates feeding behavior and host metabolism.
- Subjects :
- Neurons
Mice
Multidisciplinary
Bacteria
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Nod2 Signaling Adaptor Protein
[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Animals
Appetite
Peptidoglycan
digestive system diseases
Body Temperature
Subjects
Details
- Language :
- English
- ISSN :
- 00368075 and 10959203
- Database :
- OpenAIRE
- Journal :
- Science, Science, 2022, 376 (6590), pp.eabj3986. ⟨10.1126/science.abj3986⟩
- Accession number :
- edsair.doi.dedup.....71cc3dc45b7a7f3d6038962410bedd17