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Cortical lesion stimulates adult subventricular zone neural progenitor cell proliferation and migration to the site of injury
- Source :
- Stem Cell Research, Stem Cell Research, 2013, 11 (3), pp.965-977. ⟨10.1016/j.scr.2013.06.006⟩, Stem Cell Research, Elsevier, 2013, 11 (3), pp.965-977. ⟨10.1016/j.scr.2013.06.006⟩
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- International audience; The subventricular zone (SVZ) is the principal neurogenic niche present in the adult non-human mammalian brain. Neurons generated in the SVZ migrate along the rostral migratory stream to reach the olfactory bulb. Brain injuries stimulate SVZ neurogenesis and direct migration of new progenitors to the sites of injury. To date, cortical injury-induced adult SVZ neurogenesis in mice remains ambiguous and migration of neural progenitors to the site of injury has not been studied in detail. Here we report that aspiration lesion in the motor cortex induces a transient, but significant increase in the proliferation as well as neurogenesis in the SVZ. New neural progenitors migrate ectopically to the injured area with the assistance of blood vessels and reactive astrocytes. The SVZ origin of these progenitors was further confirmed using lentiviral transduction. In addition, we show that astrocyte-assisted ectopic migration is regulated by CXCR4/SDF-1 signaling pathway. Finally, upon reaching the lesion area, these progenitors differentiate mainly into glial cells and, to a lesser extent, mature neurons. These data provide a detailed account of the changes occurring in the SVZ and the cortex following lesion, and indicate the potential of the endogenous neural progenitors in cortical repair.
- Subjects :
- Male
MESH: Signal Transduction
Benzylamines
Rostral migratory stream
animal diseases
[SDV]Life Sciences [q-bio]
MESH: Neurons
Cyclams
Mice
0302 clinical medicine
Cell Movement
Heterocyclic Compounds
Cortex (anatomy)
MESH: Animals
MESH: Anti-HIV Agents
MESH: Cell Movement
Cerebral Cortex
Neurons
Medicine(all)
0303 health sciences
Stem Cells
Neurogenesis
General Medicine
Anatomy
[SDV] Life Sciences [q-bio]
medicine.anatomical_structure
Female
MESH: Neuroglia
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
medicine.symptom
MESH: Chemokine CXCL12
Neuroglia
MESH: Neovascularization, Physiologic
Motor cortex
Signal Transduction
Receptors, CXCR4
MESH: Heterocyclic Compounds
Anti-HIV Agents
Subventricular zone
Neovascularization, Physiologic
MESH: Stem Cells
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
MESH: Receptors, CXCR4
Lesion
03 medical and health sciences
MESH: Mice, Inbred C57BL
MESH: Cell Proliferation
medicine
Animals
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Progenitor cell
[SDV.BC] Life Sciences [q-bio]/Cellular Biology
MESH: Mice
030304 developmental biology
Cell Proliferation
Cell Biology
Chemokine CXCL12
MESH: Cerebral Cortex
MESH: Male
Olfactory bulb
MESH: Neurogenesis
Mice, Inbred C57BL
MESH: Astrocytes
nervous system
Astrocytes
Neuroscience
MESH: Female
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 18767753
- Database :
- OpenAIRE
- Journal :
- Stem Cell Research, Stem Cell Research, 2013, 11 (3), pp.965-977. ⟨10.1016/j.scr.2013.06.006⟩, Stem Cell Research, Elsevier, 2013, 11 (3), pp.965-977. ⟨10.1016/j.scr.2013.06.006⟩
- Accession number :
- edsair.doi.dedup.....71c62202cf8c8eb35782dfe4801c7622