Back to Search Start Over

Bioactive Materials for Soft Tissue Repair

Authors :
Maria Rosa Iaquinta
Anna Tampieri
Elisa Mazzoni
Simone Sprio
Fernanda Martini
Martina Maritati
Monica Montesi
Mauro Tognon
Carmen Lanzillotti
Chiara Mazziotta
Source :
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021), Frontiers in Bioengineering and Biotechnology, Frontiers in Bioengineering and Biotechnology 9 (2021). doi:10.3389/fbioe.2021.613787, info:cnr-pdr/source/autori:Mazzoni E.; Iaquinta M.R.; Lanzillotti C.; Mazziotta C.; Maritati M.; Montesi M.; Sprio S.; Tampieri A.; Tognon M.; Martini F./titolo:Bioactive Materials for Soft Tissue Repair/doi:10.3389%2Ffbioe.2021.613787/rivista:Frontiers in Bioengineering and Biotechnology/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:9
Publication Year :
2021
Publisher :
Frontiers Media SA, 2021.

Abstract

Over the past decades, age-related pathologies have increased abreast the aging population worldwide. The increased age of the population indicates that new tools, such as biomaterials/scaffolds for damaged tissues, which display high efficiency, effectively and in a limited period of time, for the regeneration of the body's tissue are needed. Indeed, scaffolds can be used as templates for three-dimensional tissue growth in order to promote the tissue healing stimulating the body's own regenerative mechanisms. In tissue engineering, several types of biomaterials are employed, such as bioceramics including calcium phosphates, bioactive glasses, and glass–ceramics. These scaffolds seem to have a high potential as biomaterials in regenerative medicine. In addition, in conjunction with other materials, such as polymers, ceramic scaffolds may be used to manufacture composite scaffolds characterized by high biocompatibility, mechanical efficiency and load-bearing capabilities that render these biomaterials suitable for regenerative medicine applications. Usually, bioceramics have been used to repair hard tissues, such as bone and dental defects. More recently, in the field of soft tissue engineering, this form of scaffold has also shown promising applications. Indeed, soft tissues are continuously exposed to damages, such as burns or mechanical traumas, tumors and degenerative pathology, and, thereby, thousands of people need remedial interventions such as biomaterials-based therapies. It is known that scaffolds can affect the ability to bind, proliferate and differentiate cells similar to those of autologous tissues. Therefore, it is important to investigate the interaction between bioceramics and somatic/stem cells derived from soft tissues in order to promote tissue healing. Biomimetic scaffolds are frequently employed as drug-delivery system using several therapeutic molecules to increase their biological performance, leading to ultimate products with innovative functionalities. This review provides an overview of essential requirements for soft tissue engineering biomaterials. Data on recent progresses of porous bioceramics and composites for tissue repair are also presented.

Details

ISSN :
22964185
Volume :
9
Database :
OpenAIRE
Journal :
Frontiers in Bioengineering and Biotechnology
Accession number :
edsair.doi.dedup.....71bed031aa6587448d3f87e36b22c791
Full Text :
https://doi.org/10.3389/fbioe.2021.613787