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Chitosan self-assembled polymeric nanoparticles for percutaneous delivery of betamethasone in contact dermatitis
- Source :
- Drug development and industrial pharmacy. 47(8)
- Publication Year :
- 2021
-
Abstract
- The study was performed with an aim to investigate the efficiency of two treatment options in experimental nickel-induced contact dermatitis (CT), with either betamethasone or chitosan cross-linked nano-encapsulated betamethasone lanoline solutions (nano-betamethasone).Male Wistar rats were used. The differences were compared based on lesion visual appearance, skinfold thickness, white blood cell count (WBC), erythrocyte sedimentation rate (ESR), blood serum prooxidant-antioxidant balance (thiobarbituric acid reactive substances, TBARS; supersoxide dismutase, SOD; catalase, KAT), blood cytokine profile (TNF-α, IL-1β, IL-10, and IL-4), and histological examination of affected skin.All animals treated with nickel sulfate developed CT and systemic inflammatory response on day 12, which only slightly lessened, if left untreated, on day 20. The therapeutic effectiveness of nano-betamethasone was significantly far superior (Nano-betamethasone may be considered as a more successful transcutaneous therapy for managing contact dermatitis compared to ointments consisting of betamethasone in traditional form.
- Subjects :
- Male
Percutaneous
Pharmaceutical Science
Dermatitis, Contact
Betamethasone
Thiobarbituric Acid Reactive Substances
Self assembled
Chitosan
chemistry.chemical_compound
Drug Discovery
medicine
Animals
Rats, Wistar
Pharmacology
Superoxide Dismutase
Tumor Necrosis Factor-alpha
Organic Chemistry
Treatment options
Polymeric nanoparticles
medicine.disease
Skin Histology
Interleukin-10
Rats
chemistry
Nanoparticles
Interleukin-4
Contact dermatitis
medicine.drug
Biomedical engineering
Subjects
Details
- ISSN :
- 15205762
- Volume :
- 47
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Drug development and industrial pharmacy
- Accession number :
- edsair.doi.dedup.....71be0345e5bc04aca932b3876f8184da