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Discovery of novel intracellular receptor modulating drugs
- Source :
- The Journal of Steroid Biochemistry and Molecular Biology. 56:61-66
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- Utilizing the co-transfection assay as a guide to determining structure activity relationships, we have been pursuing the discovery of non-steroidal hPR modulators. Small molecule, non-steroidal lead structures have been identified. Optimization of these structures has yielded more potent hPR modulators. Improved cross-reactivity profiles with other intracellular receptors are a feature of these compounds owing to their non-steroidal nature.
- Subjects :
- Agonist
Receptors, Steroid
medicine.drug_class
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Gonanes
macromolecular substances
Anisoles
Biology
Pharmacology
Transfection
Biochemistry
Structure-Activity Relationship
Hormone Antagonists
Endocrinology
Receptors, GABA
Chlorophyta
Cyclohexanes
Chlorocebus aethiops
Intracellular receptor
medicine
Animals
Humans
Receptor
Molecular Biology
Molecular Structure
Progesterone Congeners
Estrogen Replacement Therapy
Cell Biology
Small molecule
Recombinant Proteins
Mifepristone
Nuclear receptor
Drug Design
Molecular Medicine
Female
Sleep Stages
Receptors, Progesterone
Intracellular
Subjects
Details
- ISSN :
- 09600760
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- The Journal of Steroid Biochemistry and Molecular Biology
- Accession number :
- edsair.doi.dedup.....71acb76bc64801e1b9a8d078d0f1a9af