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Hyaluronan enters keratinocytes by a novel endocytic route for catabolism
- Source :
- The Journal of biological chemistry. 276(37)
- Publication Year :
- 2001
-
Abstract
- Hyaluronan synthesized in the epidermis has an exceptionally short half-life, indicative of its catabolism by epidermal keratinocytes. An intracellular pool of endogenously synthesized hyaluronan, from 1 to 20 fg/cell, inversely related to cell density, was observed in cultured rat epidermal keratinocytes. More than 80% of the intracellular hyaluronan was small (
- Subjects :
- Keratinocytes
Cytoplasm
Endosome
Endocytic cycle
Golgi Apparatus
Biology
Endocytosis
Caveolae
Biochemistry
Animals
Hyaluronic Acid
Molecular Biology
Aggrecan
Cells, Cultured
integumentary system
Vesicle
Cell Biology
Receptor-mediated endocytosis
Hyaluronan-mediated motility receptor
Cell biology
Rats
carbohydrates (lipids)
Molecular Weight
Hyaluronan Receptors
Lysosomes
Intracellular
Subjects
Details
- ISSN :
- 00219258
- Volume :
- 276
- Issue :
- 37
- Database :
- OpenAIRE
- Journal :
- The Journal of biological chemistry
- Accession number :
- edsair.doi.dedup.....71a86bb52d7ad166ce3af99ac9f4f97c