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Phosphorylcholine-Coated Silicone Implants
- Source :
- Annals of Plastic Surgery. 65:560-564
- Publication Year :
- 2010
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2010.
-
Abstract
- Introduction: The formation of capsular fibrosis around silicone breast implants is a common complication in reconstructive and plastic surgery. Foreign body reaction-induced infections are quite common because of the hydrophobic surface properties of silicone and are, in addition, considered to be a causative factor of capsular fibrosis. Methods: In this experimental pilot study, 2 groups of 7 Sprague-Dawley rats were established to evaluate the periprosthetic collagen synthesis after implantation of coated silicone implants. In the first group, the textured minisilicone implants were implanted submuscularly. The second group received the biotechnologically, surface-modified phosphorylcholine (PC)-coated implants. After a 3-month period, all the rats were killed, and the capsules were examined in a histologic (hematoxylin-eosin and Masson-trichrom) and immunohistologic way (CD4, CD8, CD68, TGF-beta, fibroblasts, collagen type I, and collagen type III). Results: Significant differences were found to occur between the PC-coated and standard, textured implants with respect to the inflammatory reaction and collagen synthesis. Conclusions: The production of hydrophilic surfaces in silicone implants by way of PC-coating causes a decrease in the inflammatory reaction, and thus, a reduction of periprosthetic fibrosis. This could form the basis of a cost-effective, preventive, and therapeutic strategy with respect to the decrease in capsular fibrosis occurrence.
- Subjects :
- medicine.medical_specialty
Pathology
Surface Properties
Breast Implants
CD8 Antigens
Phosphorylcholine
Silicones
Antigens, Differentiation, Myelomonocytic
Periprosthetic
Rats, Sprague-Dawley
Collagen Type III
chemistry.chemical_compound
Silicone
Coated Materials, Biocompatible
Antigens, CD
Transforming Growth Factor beta
Fibrosis
Joint capsule
medicine
Animals
business.industry
Foreign-Body Reaction
Fibroblasts
medicine.disease
Immunohistochemistry
Rats
Plastic surgery
medicine.anatomical_structure
chemistry
CD4 Antigens
Surgery
Collagen
Implant
business
Subjects
Details
- ISSN :
- 01487043
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- Annals of Plastic Surgery
- Accession number :
- edsair.doi.dedup.....71910b9b484572adcec0c2fcadc8884a