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The addition of pretreatment plasma Epstein-Barr virus DNA into the eighth edition of nasopharyngeal cancer TNM stage classification
- Source :
- International journal of cancer. 144(7)
- Publication Year :
- 2018
-
Abstract
- The eighth edition of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) stage classification (TNM) for nasopharyngeal carcinoma (NPC) was launched. It remains unknown if incorporation of nonanatomic factors into the stage classification would better predict survival. We prospectively recruited 518 patients with nonmetastatic NPC treated with radical intensity-modulated radiation therapy ± chemotherapy based on the eighth edition TNM. Recursive partitioning analysis (RPA) incorporating pretreatment plasma Epstein-Barr virus (EBV) DNA derived new stage groups. Multivariable analyses to calculate adjusted hazard ratios (AHRs) derived another set of stage groups. Five-year progression-free survival (PFS), overall survival (OS) and cancer-specific survival (CSS) were: Stage I (PFS 100%, OS 90%, CSS 100%), II (PFS 88%, OS 84%, CSS 95%), III (PFS 84%, OS 84%, CSS 90%) and IVA (PFS 71%, OS 75%, CSS 80%) (p < 0.001, p = 0.066 and p = 0.002, respectively). RPA derived four new stages: RPA-I (T1-T4 N0-N2 & EBV DNA
- Subjects :
- Stage classification
Male
Cancer Research
medicine.medical_specialty
Epstein-Barr Virus Infections
Herpesvirus 4, Human
medicine.medical_treatment
Recursive partitioning
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Drug Therapy
Internal medicine
medicine
Humans
Prospective Studies
Stage (cooking)
Neoplasm Staging
Chemotherapy
Nasopharyngeal Carcinoma
business.industry
Hazard ratio
Cancer
Nasopharyngeal Neoplasms
Middle Aged
medicine.disease
Prognosis
Survival Analysis
Radiation therapy
Treatment Outcome
Oncology
Nasopharyngeal carcinoma
030220 oncology & carcinogenesis
DNA, Viral
Female
Radiotherapy, Intensity-Modulated
business
Subjects
Details
- ISSN :
- 10970215
- Volume :
- 144
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- International journal of cancer
- Accession number :
- edsair.doi.dedup.....718d5a1cc8fd8fd2f20fc9cc113731bc