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Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure
- Source :
- American Journal of Physiology-Heart and Circulatory Physiology, 301(2), H459-H468. AMER PHYSIOLOGICAL SOC
- Publication Year :
- 2011
-
Abstract
- Yin M, van der Horst IC, van Melle JP, Qian C, van Gilst WH, Sillje HH, de Boer RA. Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure. Am J Physiol Heart Circ Physiol 301: H459-H468, 2011. First published May 13, 2011; doi:10.1152/ajpheart.00054.2011.-Metformin is the first choice drug for the treatment of patients with diabetes, but its use is debated in patients with advanced cardiorenal disease. Epidemiological data suggest that metformin may reduce cardiac events, in patients both with and without heart failure. Experimental evidence suggests that metformin reduces cardiac ischemia-reperfusion injury. It is unknown whether metformin improves cardiac function (remodeling) in a long-term post-MI remodeling model. We therefore studied male, nondiabetic, Sprague-Dawley rats that were subjected to either myocardial infarction (MI) or sham operation. Animals were randomly allocated to treatment with normal water or metformin-containing water (250 mg.kg(-1).day(-1)). At baseline, 6 wk, and 12 wk, metabolic parameters were analyzed and oral glucose tolerance tests (OGTT) were performed. Echocardiography and hemodynamic parameters were assessed 12 wk after MI. In the MI model, infarct size was significantly smaller after 12-wk metformin treatment (29.6 +/- 3.2 vs. 38.0 +/- 2.2%, P
- Subjects :
- Blood Glucose
Male
Time Factors
endocrine system diseases
Physiology
PROGRESSION
AMP-Activated Protein Kinases
Ventricular Function, Left
Muscle hypertrophy
Rats, Sprague-Dawley
Insulin
Myocardial infarction
Phosphorylation
IN-VIVO
remodeling
Glucose tolerance test
OUTCOMES
Ventricular Remodeling
medicine.diagnostic_test
diabetes
ACTIVATED PROTEIN-KINASE
Metformin
myocardial infarction
Cardiology
Hypertrophy, Left Ventricular
Cardiology and Cardiovascular Medicine
Atrial Natriuretic Factor
medicine.drug
Cardiac function curve
medicine.medical_specialty
Cardiotonic Agents
METABOLISM
left ventricular function
CARDIOPROTECTION
Physiology (medical)
Diabetes mellitus
Internal medicine
medicine
Animals
Hypoglycemic Agents
CELL
Heart Failure
business.industry
Myocardium
nutritional and metabolic diseases
Stroke Volume
DIABETES-MELLITUS
Glucose Tolerance Test
medicine.disease
Fibrosis
Rats
HYPERTROPHY
Disease Models, Animal
Gene Expression Regulation
MYOCARDIAL-INFARCTION
Heart failure
Myocardial infarction complications
Energy Metabolism
business
Subjects
Details
- Language :
- English
- ISSN :
- 03636135
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Heart and Circulatory Physiology, 301(2), H459-H468. AMER PHYSIOLOGICAL SOC
- Accession number :
- edsair.doi.dedup.....718c3bd2bc627d73161200423418bd23