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Sarcopenia and Visceral Metastasis at Cabazitaxel Initiation Predict Prognosis in Patients With Castration-resistant Prostate Cancer Receiving Cabazitaxel Chemotherapy
- Source :
- In Vivo
- Publication Year :
- 2021
- Publisher :
- Anticancer Research USA Inc., 2021.
-
Abstract
- Background/aim Cabazitaxel is recommended as first-line treatment after docetaxel for metastatic castration-resistant prostate cancer. However, the efficacy, adverse events and prognostic factors associated with cabazitaxel are unclear. Patients and methods This single-centre retrospective study including 30 patients with CRPC treated with cabazitaxel between 2014 and 2020 investigated efficacy, outcomes and prognostic factors. Results Fourteen patients had visceral metastases. The median cabazitaxel dose was 20 mg/m2 The prostate-specific antigen response rate, time to prostate-specific antigen response, and overall survival were 13.3%, 3.48 months, and 7.92 months, respectively. The rates of grade 3 or more neutropenia and febrile neutropenia were 20% and 6.7%, respectively. By multivariate analysis, sarcopenia and visceral metastasis at the time of cabazitaxel initiation were independent and significant factors conferring a poor prognosis. Conclusion The early introduction of cabazitaxel, prior to the development of sarcopenia and visceral metastasis, might contribute to improved prognosis in CRPC.
- Subjects :
- Male
Oncology
Sarcopenia
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Neutropenia
General Biochemistry, Genetics and Molecular Biology
Prostate cancer
Internal medicine
Humans
Medicine
Neoplasm Metastasis
Adverse effect
Retrospective Studies
Pharmacology
Chemotherapy
business.industry
Prognosis
medicine.disease
Prostatic Neoplasms, Castration-Resistant
Treatment Outcome
Docetaxel
Cabazitaxel
Taxoids
business
Febrile neutropenia
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 17917549 and 0258851X
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- In Vivo
- Accession number :
- edsair.doi.dedup.....71621d7158bc443161dd96b07d77e12d