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Vaccine mediated protection against Zika virus induced congenital disease
Vaccine mediated protection against Zika virus induced congenital disease
- Publication Year :
- 2017
-
Abstract
- The emergence of Zika virus (ZIKV) and its association with congenital malformations has prompted the rapid development of vaccines. Although efficacy with nucleic acid or inactivated viral vaccine platforms has been established in animals, no study has addressed protection during pregnancy. We tested in mice two vaccine platforms, a lipid nanoparticle-encapsulated modified mRNA vaccine encoding ZIKV prM and E genes and a live-attenuated ZIKV strain encoding an NS1 protein without glycosylation, for their ability to protect against transmission to the fetus. Vaccinated dams challenged with a heterologous ZIKV strain at embryo day 6 (E6) and evaluated at E13 showed markedly diminished levels of viral RNA in maternal, placental, and fetal tissues, which resulted in protection against placental damage and fetal demise. As modified mRNA and live-attenuated vaccine platforms can restrict in utero transmission of ZIKV in mice, their further development in humans to prevent congenital ZIKV syndrome is warranted.
- Subjects :
- 0301 basic medicine
Male
030106 microbiology
Heterologous
Viral Nonstructural Proteins
Antibodies, Viral
General Biochemistry, Genetics and Molecular Biology
Article
Zika virus
03 medical and health sciences
Mice
Fetus
Immunity
Aedes
Animals
Humans
RNA, Messenger
Blood Cells
biology
Transmission (medicine)
Zika Virus Infection
Viral Vaccine
Viral Vaccines
Zika Virus
biology.organism_classification
Embryo, Mammalian
Virology
Antibodies, Neutralizing
Lipids
Specific Pathogen-Free Organisms
Mice, Inbred C57BL
Flavivirus
030104 developmental biology
Immunology
Mutation
Vaccines, Subunit
biology.protein
Female
Antibody
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....7160aaca4f5f7b44ee64092c3a15bf8c