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Vaccine mediated protection against Zika virus induced congenital disease

Vaccine mediated protection against Zika virus induced congenital disease

Authors :
Theodore C. Pierson
Pedro Fernando da Costa Vasconcelos
Pei Yong Shi
Daniele Barbosa de Almeida Medeiros
Indira U. Mysorekar
Kimberly A. Dowd
Justin M. Richner
Camila R. Fontes
Brett W. Jagger
Bruno Tardelli Diniz Nunes
Chao Shan
Sunny Himansu
Bryant M. Foreman
Antonio E. Muruato
Shannan L. Rossi
Giuseppe Ciaramella
Huanle Luo
Bin Cao
Alan D.T. Barrett
Scott C. Weaver
Michael S. Diamond
Tian Wang
Elizabeth A. Caine
Publication Year :
2017

Abstract

The emergence of Zika virus (ZIKV) and its association with congenital malformations has prompted the rapid development of vaccines. Although efficacy with nucleic acid or inactivated viral vaccine platforms has been established in animals, no study has addressed protection during pregnancy. We tested in mice two vaccine platforms, a lipid nanoparticle-encapsulated modified mRNA vaccine encoding ZIKV prM and E genes and a live-attenuated ZIKV strain encoding an NS1 protein without glycosylation, for their ability to protect against transmission to the fetus. Vaccinated dams challenged with a heterologous ZIKV strain at embryo day 6 (E6) and evaluated at E13 showed markedly diminished levels of viral RNA in maternal, placental, and fetal tissues, which resulted in protection against placental damage and fetal demise. As modified mRNA and live-attenuated vaccine platforms can restrict in utero transmission of ZIKV in mice, their further development in humans to prevent congenital ZIKV syndrome is warranted.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....7160aaca4f5f7b44ee64092c3a15bf8c