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Cardiovascular manifestations in obstructive sleep apnea: current evidence and potential mechanisms
- Source :
- Polish archives of internal medicine. 131(6)
- Publication Year :
- 2021
-
Abstract
- Obstructive sleep apnea (OSA) is an increasingly prevalent health concern characterized by repeated episodes of pharyngeal collapse during sleep. It is frequently associated with daytime sleepiness and impaired functional capacity, but it is also linked to cardiovascular disease by a growing body of epidemiological, clinical, and translational research. The severity of OSA is traditionally evaluated by the apnea‑hypopnea index (AHI), but the value of this marker as a predictor of cardiovascular outcomes is limited. Thus, there is an increasing focus on alternative classification methods such as the hypoxic burden, other polysomnographic traits, and phenotypic subgroups based on clinical symptoms. There is a need to identify subgroups of patients with OSA who will benefit most from treatment, as recent large randomized controlled trials in selected populations have failed to show benefit in reducing overall cardiovascular mortality. Obstructive sleep apnea adversely affects cardiovascular structure and function by several distinct mechanisms such as intermittent hypoxia, sleep fragmentation, and intrathoracic pressure swings. These mechanisms lead to sympathetic activation, inflammation, and oxidative stress, which may result in the clinical consequences of OSA such as hypertension, coronary artery disease, heart failure, and cerebrovascular disease. This review focuses on the epidemiology and potential mechanisms of cardiovascular diseases in OSA. Furthermore, we will briefly discuss the role of personalized medicine, alternative treatment options, and precise phenotyping to optimize treatment of this complex condition and its associated cardiovascular risk.
- Subjects :
- medicine.medical_specialty
Sleep Apnea, Obstructive
business.industry
Intermittent hypoxia
Disease
medicine.disease
Cardiovascular System
respiratory tract diseases
law.invention
Coronary artery disease
Obstructive sleep apnea
Randomized controlled trial
law
Cardiovascular Diseases
Heart failure
Epidemiology
Hypertension
Internal Medicine
medicine
Humans
Personalized medicine
business
Intensive care medicine
Hypoxia
Subjects
Details
- ISSN :
- 18979483
- Volume :
- 131
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Polish archives of internal medicine
- Accession number :
- edsair.doi.dedup.....71562ecde772314a2837fe74ca37cfd6