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Listeriosis Cases and Genetic Diversity of Their L. monocytogenes Isolates in China, 2008–2019

Authors :
Binghuai Lu
Junwen Yang
Chunyan Gao
Dong Li
Yanchao Cui
Lei Huang
Xingchun Chen
Duochun Wang
Aiping Wang
Yulei Liu
Yi Li
Zhijun Zhang
Mingyuan Jiao
Heping Xu
Yu Song
Baoqing Fu
Lili Xu
Qing Yang
Yongzhong Ning
Lijun Wang
Chunmei Bao
Guolan Luo
Hua Wu
Tongshu Yang
Chen Li
Manjuan Tang
Junrui Wang
Wenchen Guo
Ji Zeng
Wen Zhong
Source :
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021), Frontiers in Cellular and Infection Microbiology
Publication Year :
2021
Publisher :
Frontiers Media S.A., 2021.

Abstract

Listeriosis, caused by Listeria monocytogenes, is a severe food-borne infection. The nationwide surveillance in China concerning listeriosis is urgently needed. In the present study, 144 L. monocytogenes isolates were collected from the samples of blood, cerebrospinal fluid (CSF), and fetal membrane/placenta in China for 12 years from 2008 to 2019. We summarized these listeriosis patients’ demographical and clinical features and outcomes. The susceptibility profile for 12 antibiotics was also determined by the broth microdilution method. Multilocus sequence typing (MLST) and serogroups of these listeria isolates were analyzed to designate epidemiological types. We enrolled 144 cases from 29 healthcare centers, including 96 maternal-neonatal infections, 33 cases of bacteremia, 13 cases of neurolisteriosis, and two cutaneous listeriosis. There were 31 (59.6%) fetal loss in 52 pregnant women and four (9.8%) neonatal death in 41 newborns. Among the 48 nonmaternal-neonatal cases, 12.5% (6/48) died, 41.7% (20/48) were female, and 64.6% (31/48) occurred in those with significant comorbidities. By MLST, the strains were distinguished into 23 individual sequence types (STs). The most prevalent ST was ST87 (49 isolates, 34.0%), followed by ST1 (18, 12.5%), ST8 (10, 6.9%), ST619 (9, 6.3%), ST7 (7, 4.9%) and ST3 (7, 4.9%). Furthermore, all L. monocytogenes isolates were uniformly susceptible to penicillin, ampicillin, and meropenem. In summary, our study highlights a high genotypic diversity of L. monocytogenes strains causing clinical listeriosis in China. Furthermore, a high prevalence of ST87 and ST1 in the listeriosis should be noted.

Details

Language :
English
ISSN :
22352988
Volume :
11
Database :
OpenAIRE
Journal :
Frontiers in Cellular and Infection Microbiology
Accession number :
edsair.doi.dedup.....714e0dbdd436e468a8033be0af7b9efe