Back to Search
Start Over
The Relationship between Plasma Erythropoietin Levels and Symptoms of Attention Deficit Hyperactivity Disorder
- Source :
- Clinical Psychopharmacology and Neuroscience
- Publication Year :
- 2021
- Publisher :
- Korean College of Neuropsychopharmacology, 2021.
-
Abstract
- Objective There are animal models associating dopamine dysfunction with behavioral impairments that model attention deficit hyperactivity disorder (ADHD). Erythropoietin (EPO) has trophic effects on dopaminergic neurons. The aim of this study was to examine the EPO plasma levels and determine whether there was any correlation between plasma EPO levels and clinical characteristics of ADHD. Methods Plasma EPO levels were measured in 78 drug-naive children with ADHD and in 81 healthy children. The severity of ADHD symptoms was determined by scores on the Korean ADHD Rating Scale (K-ARS) in ADHD children and healthy controls. Results The difference between median plasma EPO levels in ADHD children and in healthy controls was not statistically significant. Adjusting for age and sex, a linear regression analysis showed that inattention score was significantly higher in the second highest tertile of plasma EPO compared to those in the lowest tertile. Hyperactivity-impulsivity score was significantly higher in the highest tertile of plasma EPO compared to those in the lowest tertile. Moreover, total K-ARS scores were significantly higher in the second highest tertile of plasma EPO compared to those in the lowest tertile. Conclusion These findings suggest that plasma EPO levels were related to some ADHD symptoms, which could be used in the monitoring of the disorder.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
030106 microbiology
Erythropoietin levels
Age and sex
Attention deficit hyperactivity disorder
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Dopamine
Rating scale
hemic and lymphatic diseases
Internal medicine
mental disorders
Neurodevelopment
medicine
Pharmacology (medical)
030212 general & internal medicine
Erythropoietin
business.industry
Dopaminergic
Plasma levels
medicine.disease
Neuroprotection
Psychiatry and Mental health
Endocrinology
Original Article
business
medicine.drug
Subjects
Details
- ISSN :
- 20934327 and 17381088
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Clinical Psychopharmacology and Neuroscience
- Accession number :
- edsair.doi.dedup.....7141d472ad9b44b2bb25a6441af82c75